NP_001623.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alkaline phosphatase, placental type preproprotein
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Protein Information
alkaline phosphatase, placental type
UniProt Protein Name
Alkaline phosphatase, placental type
UniProt Synonym Protein Names
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
UniProt Synonym Gene Names
UniProt Entry Name
PPB1_HUMAN
NCBI Summary for ALPP
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
Product References and Citations for anti-ALPP antibody
Millan J.L. et. al., Antigenic determinants of human placental and testicular alkaline phosphatase as mapped by monoclonal antibodies. Eur. J. Biochem. 136: 1-12, (1983). Riklund K.E. et. al., Experimental radio-immunotherapy of HeLa tumors in nude mice with 131I-labeled monoclonal antibodies. Anticancer Research, 1990, 10:379-84
Research Articles on ALPP
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Pathways associated with anti-ALPP antibody
Diseases associated with anti-ALPP antibody
Organs/Tissues associated with anti-ALPP antibody
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