NP_001634.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,175 Da
NCBI Official Full Name
apolipoprotein A-II preproprotein
NCBI Official Synonym Full Names
apolipoprotein A-II
NCBI Protein Information
apolipoprotein A-II; apolipoprotein A2
UniProt Protein Name
Apolipoprotein A-II
UniProt Synonym Protein Names
Apolipoprotein A2
UniProt Synonym Gene Names
UniProt Entry Name
APOA2_HUMAN
NCBI Summary for Apo AII
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
UniProt Comments for Apo AII
Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Subunit structure: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1. Ref.15 Ref.16 Ref.19 Ref.23
Subcellular location: Secreted.
Tissue specificity: Plasma; synthesized in the liver and intestine.
Post-translational modification: Met-49 is oxidized to methionine sulfoxide.Phosphorylation sites are present in the extracellular medium.Apolipoprotein A-II is O-glycosylated. Ref.22
Polymorphism: A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [
MIM:107670].
Sequence similarities: Belongs to the apolipoprotein A2 family.
Mass spectrometry: Molecular mass is 17252 Da from positions 24 - 100. Determined by ESI. Homodimer, without methionine sulfoxide. Ref.17Molecular mass is 17269 Da from positions 24 - 100. Determined by ESI. Homodimer, with 1 methionine sulfoxide, oxidation at Met-49. Ref.17Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. Ref.18Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II. Ref.18Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer. Ref.18Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with truncated apolipoprotein A-II. Ref.18Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. Ref.18Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer. Ref.18
Research Articles on Apo AII
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Products associated with anti-Apo AII antibody
Pathways associated with anti-Apo AII antibody
Diseases associated with anti-Apo AII antibody
Organs/Tissues associated with anti-Apo AII antibody
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