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anti-Apo AII antibody :: Goat Apolipoprotein AII Antibody

Scan QR to view Datasheet Catalog #    MBS390011 anti-Apo AII antibody
Unit / Price
0.5 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein AII (Apo AII), Antibody

 Also Known As   

FITC-conjugated Goat Anti-Human Apolipoprotein AII

 Product Synonym Names    FITC conjugated Goat Anti-Human Apolipoprotein AII (Apo AII), Polyclonal Antibody
 Product Gene Name   

anti-Apo AII antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (161192083..161193418, complement). Location: 1q23.3
 OMIM    107670
 3D Structure    ModBase 3D Structure for P02652
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 Host    Goat
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 Specificity    Specifically binds to human apo AII. Molar F/P ratio is 4.7. The investigator should determine working dilutions.
 Form/Format    0.5 ml in Freeze-dried powder
 Concentration    1 mg / ml (lot specific)
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 Source Note    Polyclonal antibody purified by human apo AII-Sepharose affinity column and labeled with FITC.
 Preservative    75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.4.
 Stabilizer    5 mg / ml Bovine Serum Albumin
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 Preparation and Storage    Freeze-dried product should be refrigerated until opened. After opening, restore to 0.5 ml with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4 degree C as an undiluted liquid. Do not use for more than one day after dilution. The products are light sensitive and should be keep in dark. To avoid repeated freezing and thawing after reconstitution, we suggest aliquots and storage at -20 degree C.
 Other Notes    Small volumes of anti-Apo AII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Apo AII antibody    FITC Antibodies
 Applications Tested/Suitable for anti-Apo AII antibody   

Immunofluorescence (IF)

 Application Notes for anti-Apo AII antibody    Molar F/P Ratio: 4.7. Freeze-dried powder.
Use: The antibody can be used to detect the existence of apo AII with immuno-fluoroscent approach.
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NCBI/Uniprot data below describe general gene information for Apo AII. It may not necessarily be applicable to this product.
 NCBI GI #    4502149
 NCBI GeneID    336
 NCBI Accession #    NP_001634.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001643.1 [Other Products]
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 UniProt Primary Accession #    P02652 [Other Products]
 UniProt Secondary Accession #    B2R524 [Other Products]
 UniProt Related Accession #    P02652 [Other Products]
 Molecular Weight    11,175 Da
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 NCBI Official Full Name    apolipoprotein A-II preproprotein
 NCBI Official Synonym Full Names    apolipoprotein A-II
 NCBI Official Symbol    APOA2 [Similar Products]
 NCBI Official Synonym Symbols   
apoAII; Apo-AII; ApoA-II
[Similar Products]
 NCBI Protein Information    apolipoprotein A-II; apolipoprotein A2
 UniProt Protein Name    Apolipoprotein A-II
 UniProt Synonym Protein Names   
Apolipoprotein A2Cleaved into the following chain:Truncated apolipoprotein A-II; Alternative name(s):; Apolipoprotein A-II(1-76)
 UniProt Gene Name    APOA2 [Similar Products]
 UniProt Synonym Gene Names    Apo-AII; ApoA-II [Similar Products]
 UniProt Entry Name    APOA2_HUMAN
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 NCBI Summary for Apo AII    This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Apo AII    Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Subunit structure: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1. Ref.15 Ref.16 Ref.19 Ref.23

Subcellular location: Secreted.

Tissue specificity: Plasma; synthesized in the liver and intestine.

Post-translational modification: Met-49 is oxidized to methionine sulfoxide.Phosphorylation sites are present in the extracellular medium.Apolipoprotein A-II is O-glycosylated. Ref.22

Polymorphism: A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [

MIM:107670].

Sequence similarities: Belongs to the apolipoprotein A2 family.

Mass spectrometry: Molecular mass is 17252 Da from positions 24 - 100. Determined by ESI. Homodimer, without methionine sulfoxide. Ref.17Molecular mass is 17269 Da from positions 24 - 100. Determined by ESI. Homodimer, with 1 methionine sulfoxide, oxidation at Met-49. Ref.17Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. Ref.18Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II. Ref.18Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer. Ref.18Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with truncated apolipoprotein A-II. Ref.18Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. Ref.18Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer. Ref.18
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 Research Articles on Apo AII    1. Clinical studies demonstrate that apoA-II is a strong predictor of risk for CVD. There is no evidence, however, that selective therapeutic modification of apoA-II impacts on atherosclerosis and clinical outcomes.[review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Apo AII antibodyPathways associated with anti-Apo AII antibody
 Reference Product  PubMed Publications
 APOA1 antibody  >33 publications with Apo AII and APOA1
 APOE antibody  >15 publications with Apo AII and APOE
 APOB antibody  >14 publications with Apo AII and APOB
 APOC2 antibody  >11 publications with Apo AII and APOC2
 APOC3 antibody  >8 publications with Apo AII and APOC3
 APOA5 antibody  >4 publications with Apo AII and APOA5
 APOA4 antibody  >4 publications with Apo AII and APOA4
 LPL antibody  >4 publications with Apo AII and LPL
 MTTP antibody  >1 publications with Apo AII and MTTP
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-Apo AII antibodyOrgans/Tissues associated with anti-Apo AII antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >20 publications with Apo AII and Cardiovascular Diseases
 Dyslipidemias Antibodies  >16 publications with Apo AII and Dyslipidemias
 Heart Diseases Antibodies  >12 publications with Apo AII and Heart Diseases
 Hyperlipidemias Antibodies  >12 publications with Apo AII and Hyperlipidemias
 Liver Diseases Antibodies  >11 publications with Apo AII and Liver Diseases
 Inflammation Antibodies  >7 publications with Apo AII and Inflammation
 Carcinoma, Hepatocellular Antibodies  >5 publications with Apo AII and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >5 publications with Apo AII and Kidney Diseases
 Hypertriglyceridemia Antibodies  >5 publications with Apo AII and Hypertriglyceridemia
 Liver Neoplasms Antibodies  >5 publications with Apo AII and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >63 publications with Apo AII and Blood
 Liver Antibodies  >21 publications with Apo AII and Liver
 Heart Antibodies  >13 publications with Apo AII and Heart
 Kidney Antibodies  >8 publications with Apo AII and Kidney
 Muscle Antibodies  >5 publications with Apo AII and Muscle
 Intestine Antibodies  >5 publications with Apo AII and Intestine
 Brain Antibodies  >3 publications with Apo AII and Brain
 Placenta Antibodies  >3 publications with Apo AII and Placenta
 Lung Antibodies  >2 publications with Apo AII and Lung
 Spleen Antibodies  >2 publications with Apo AII and Spleen
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