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anti-Apo CII antibody :: Goat Apolipoprotein CII Antibody

Scan QR to view Datasheet Catalog #    MBS390021 anti-Apo CII antibody
Unit / Price
0.5 mL  /  $315 +1 FREE 8GB USB
1 mL  /  $470 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein CII (Apo CII), Antibody

 Also Known As   

Biotinylated Goat Anti-Human Apolipoprotein CII

 Product Synonym Names    Biotinylated Sheep Anti-Human Apolipoprotein CII (apoCII),Polyclonal Antibody
 Product Gene Name   

anti-Apo CII antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (45449239..45452822). Location: 19q13.2
 OMIM    207750
 3D Structure    ModBase 3D Structure for P02655
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 Host    Goat
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 Specificity    Specifically binds to human apoCII. Dilution for immunoblot and ELISA range: 200 to 5,000
 Concentration    1.2 mg / ml (lot specific)
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 Source Note    Polyclonal antibody purified by human apolipoprotein
 Preservative    10 mM PBS, 0.14 M NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2.
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 Preparation and Storage    -20 degree C for long-term storage, 2-8 degree C for short-term storage. Aliquot to avoid repeated thaw and freeze.
 Other Notes    Small volumes of anti-Apo CII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Apo CII antibody    Biotin Antibodies
 Applications Tested/Suitable for anti-Apo CII antibody   

ELISA (EIA), Immunoblot (IB)

 Application Notes for anti-Apo CII antibody    Freeze-dried powder. Dilution for Immunoblot & ELISA range: 1,000 to 5,000.
Use: The antibody can be used for detection of apoCII in human plasma and lipoproteins, immunoassays and immunoblots.
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NCBI/Uniprot data below describe general gene information for Apo CII. It may not necessarily be applicable to this product.
 NCBI GI #    32130518
 NCBI GeneID    344
 NCBI Accession #    NP_000474.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000483.4 [Other Products]
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 UniProt Primary Accession #    P02655 [Other Products]
 UniProt Secondary Accession #    Q9BS39; Q9UDE3; Q9UNK3; C0JYY4 [Other Products]
 UniProt Related Accession #    P02655 [Other Products]
 Molecular Weight    11,284 Da
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 NCBI Official Full Name    apolipoprotein C-II
 NCBI Official Synonym Full Names    apolipoprotein C-II
 NCBI Official Symbol    APOC2 [Similar Products]
 NCBI Official Synonym Symbols   
APO-CII; APOC-II
[Similar Products]
 NCBI Protein Information    apolipoprotein C-II; apolipoprotein C2
 UniProt Protein Name    Apolipoprotein C-II
 UniProt Synonym Protein Names   
Apolipoprotein C2
 UniProt Gene Name    APOC2 [Similar Products]
 UniProt Synonym Gene Names    APC2; Apo-CII; ApoC-II [Similar Products]
 UniProt Entry Name    APOC2_HUMAN
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 NCBI Summary for Apo CII    This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
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 UniProt Comments for Apo CII    Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Subcellular location: Secreted.

Tissue specificity: Secreted in plasma.

Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Sequence similarities: Belongs to the apolipoprotein C2 family.
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 Research Articles on Apo CII    1. STAT1 bound on multienhancer 2 cooperates with RXRalpha located on apoCII promoter and upregulates apoCII expression only in macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Apo CII antibodyPathways associated with anti-Apo CII antibody
 Reference Product  PubMed Publications
 APOE antibody  >220 publications with Apo CII and APOE
 LPL antibody  >167 publications with Apo CII and LPL
 APOB antibody  >137 publications with Apo CII and APOB
 APOA5 antibody  >23 publications with Apo CII and APOA5
 APOA2 antibody  >11 publications with Apo CII and APOA2
 APOC3 antibody  >11 publications with Apo CII and APOC3
 APOA1 antibody  >8 publications with Apo CII and APOA1
 APOA4 antibody  >6 publications with Apo CII and APOA4
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-Apo CII antibodyOrgans/Tissues associated with anti-Apo CII antibody
 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >251 publications with Apo CII and Dyslipidemias
 Cardiovascular Diseases Antibodies  >91 publications with Apo CII and Cardiovascular Diseases
 Atherosclerosis Antibodies  >84 publications with Apo CII and Atherosclerosis
 Hyperlipoproteinemia Type I Antibodies  >41 publications with Apo CII and Hyperlipoproteinemia Type I
 Liver Diseases Antibodies  >29 publications with Apo CII and Liver Diseases
 Kidney Diseases Antibodies  >28 publications with Apo CII and Kidney Diseases
 Fatty Liver Antibodies  >23 publications with Apo CII and Fatty Liver
 Neoplasms Antibodies  >23 publications with Apo CII and Neoplasms
 Brain Diseases Antibodies  >23 publications with Apo CII and Brain Diseases
 Carcinoma Antibodies  >12 publications with Apo CII and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >144 publications with Apo CII and Liver
 Heart Antibodies  >77 publications with Apo CII and Heart
 Kidney Antibodies  >30 publications with Apo CII and Kidney
 Intestine Antibodies  >26 publications with Apo CII and Intestine
 Lung Antibodies  >20 publications with Apo CII and Lung
 Brain Antibodies  >17 publications with Apo CII and Brain
 Skin Antibodies  >7 publications with Apo CII and Skin
 Ovary Antibodies  >7 publications with Apo CII and Ovary
 Embryonic Tissue Antibodies  >6 publications with Apo CII and Embryonic Tissue
 Eye Antibodies  >5 publications with Apo CII and Eye
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