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anti-Apo CIII antibody :: Apolipoprotein CIII Antibody

Scan QR to view Datasheet Catalog #    MBS390084
Testing Data)
Unit / Price
0.5 mg  /  $350 +1 FREE 8GB USB
1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein CIII (Apo CIII), Antibody

★Popular Item★
 Also Known As   

Rabbit Anti-Human Apolipoprotein CIII Affinity Pure

 Product Synonym Names    Rabbit Anti-Human Apolipoprotein CIII (Apo CIII), Polyclonal Antibody; Affinity Purified
 Product Gene Name   

anti-Apo CIII antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (116700624..116703787). Location: 11q23.3
 OMIM    107720
 3D Structure    ModBase 3D Structure for P02656
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 Host    Host: Rabbit

Source: Polycloonal antibody purified by human apo CIII-Sepharose affinity column and removed possible anti-apoAI by human apoAI-Sepharose affinity column.
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 Specificity    Specifically binds to human apo CIII. Dilution for immunoblot and ELISA range: 200 to 40,000.
 Concentration    1 mg / ml (OD 1.35 / 280 nm). (lot specific)
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 Source Note    Polyclonal antibody purified by human apo CIII-Sepharose affinity column.
 Preservative    75mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA,0.02% NaN3, pH 7.2.
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 Preparation and Storage    -20 degree C for long-term storage, 4 degree C for short-term storage. Aliquot to avoid repeated thaw and freeze.
 Other Notes    Small volumes of anti-Apo CIII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Apo CIII antibody    Aff. Pure AB
 Applications Tested/Suitable for anti-Apo CIII antibody   

ELISA (EIA), Immunoblot (IB)

 Application Notes for anti-Apo CIII antibody    Dilution for Immunoblot & ELISA range: 1,000 to 40,000.
Use: The antibody can be used for detection of apo CIII in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation.
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 Testing Data) of anti-Apo CIII antibody    anti-Apo CIII antibody Testing Data) image
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NCBI/Uniprot data below describe general gene information for Apo CIII. It may not necessarily be applicable to this product.
 NCBI GI #    4557323
 NCBI GeneID    345
 NCBI Accession #    NP_000031.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000040.1 [Other Products]
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 UniProt Primary Accession #    P02656 [Other Products]
 UniProt Secondary Accession #    Q08E83; Q6Q786 [Other Products]
 UniProt Related Accession #    P02656 [Other Products]
 Molecular Weight    10,852 Da
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 NCBI Official Full Name    apolipoprotein C-III
 NCBI Official Synonym Full Names    apolipoprotein C-III
 NCBI Official Symbol    APOC3 [Similar Products]
 NCBI Official Synonym Symbols   
HALP2; APOCIII
[Similar Products]
 NCBI Protein Information    apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3
 UniProt Protein Name    Apolipoprotein C-III
 UniProt Synonym Protein Names   
Apolipoprotein C3
 UniProt Gene Name    APOC3 [Similar Products]
 UniProt Synonym Gene Names    Apo-CIII; ApoC-III [Similar Products]
 UniProt Entry Name    APOC3_HUMAN
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 NCBI Summary for Apo CIII    Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Apo CIII    Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular location: Secreted.

Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Post-translational modification: The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.11 Ref.12

Involvement in disease: Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Sequence similarities: Belongs to the apolipoprotein C3 family.
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 Research Articles on Apo CIII    1. Measurement of plasma ApoCIII may improve CAD prediction in the general population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Apo CIII antibodyPathways associated with anti-Apo CIII antibody
 Reference Product  PubMed Publications
 APOE antibody  >63 publications with Apo CIII and APOE
 APOA5 antibody  >60 publications with Apo CIII and APOA5
 APOA1 antibody  >58 publications with Apo CIII and APOA1
 LPL antibody  >46 publications with Apo CIII and LPL
 APOB antibody  >44 publications with Apo CIII and APOB
 APOA4 antibody  >37 publications with Apo CIII and APOA4
 APOC2 antibody  >11 publications with Apo CIII and APOC2
 APOA2 antibody  >8 publications with Apo CIII and APOA2
 PPARG antibody  >5 publications with Apo CIII and PPARG
 INS antibody  >2 publications with Apo CIII and INS
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-Apo CIII antibodyOrgans/Tissues associated with anti-Apo CIII antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >71 publications with Apo CIII and Cardiovascular Diseases
 Coronary Disease Antibodies  >48 publications with Apo CIII and Coronary Disease
 Dyslipidemias Antibodies  >45 publications with Apo CIII and Dyslipidemias
 Hypertriglyceridemia Antibodies  >44 publications with Apo CIII and Hypertriglyceridemia
 Heart Diseases Antibodies  >44 publications with Apo CIII and Heart Diseases
 Hyperlipidemias Antibodies  >37 publications with Apo CIII and Hyperlipidemias
 Atherosclerosis Antibodies  >33 publications with Apo CIII and Atherosclerosis
 Insulin Resistance Antibodies  >32 publications with Apo CIII and Insulin Resistance
 Obesity Antibodies  >28 publications with Apo CIII and Obesity
 Hyperinsulinism Antibodies  >26 publications with Apo CIII and Hyperinsulinism
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >41 publications with Apo CIII and Liver
 Heart Antibodies  >36 publications with Apo CIII and Heart
 Connective Tissue Antibodies  >7 publications with Apo CIII and Connective Tissue
 Kidney Antibodies  >4 publications with Apo CIII and Kidney
 Muscle Antibodies  >2 publications with Apo CIII and Muscle
 Brain Antibodies  >2 publications with Apo CIII and Brain
 Lung Antibodies  >1 publications with Apo CIII and Lung
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