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anti-APOE antibody :: Goat Apolipoprotein E Antibody

Scan QR to view Datasheet Catalog #    MBS686029
SDS-PAGE
Unit / Price
1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein E (APOE), Antibody

 Also Known As   

Goat anti-Apolipoprotein E - Affinity Pure

 Product Gene Name   

anti-APOE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104310
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 Host    Goat
 Species Reactivity    Apolipoprotein E
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 Specificity    Human Apolipoprotein E
 Purity/Purification    Affinity purified using solid phase Human Apolipoprotein E
> 95% based on SDS-PAGE
 Form/Format    Clear, colorless liquid, 0.2 um filtered
 Concentration    > 4.5 mg/ml (E 1% at 280 nm = 13.0) (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Human Apolipoprotein E
 Buffer    10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
 Preservative    0.05% (w/v) Sodium Azide
 Country Of Origin    Goat serum was obtained from healthy animals of US origin and under the care of a registered veterinarian.
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 Preparation and Storage    2-8 degree C
Shelf life: 36 Months
 Other Notes    Small volumes of anti-APOE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for APOE purchase    With the increasing correlation between cholesterol and Alzheimer Disease, cholesterol transporting proteins like the apolipoprotein family, typified by ApoE, are the subject of multiple studies. The addition of a goat anti apolipoprotein 3 antibody to previously cataloged mouse or rat monoclonal antibody or rabbit polyclonal ApoE primary antibodies allows more flexible detection by western blot, ELISA or IHC since anti goat rabbit IgG Alexa fluorâ® or Alexa 174 fluor secondary antibodies may be used as reagents. This ApoE polyclonal antibody production was sourced from US human peptide immunized serum and is ideal for cell lysate analysis, metabolism related studies of cholesterol transport or custom applications. Anti ApoE antibody is species reactivity human specific, non-reactive to protein family members and validated by WB in protein lysates, included in the product datasheet. Other apolipoprotein antibody products, custom antibody production for protein family antibodies in this products category and related reagents are available.
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Product Description specifically for anti-APOE antibody

   Goat anti-Apolipoprotein E - Affinity Pure
 Product Categories/Family for anti-APOE antibody    Primary Antibodies
 Applications Tested/Suitable for anti-APOE antibody   

Immunoassay (IA)

 Application Notes for anti-APOE antibody    This antibody is suitable for all immunoassay applications. The optimal working dilution should be determined by the investigator.
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 SDS-PAGE of anti-APOE antibody    Appearance: Clear, colorless liquid
Purity: Two predominant bands at 50 and 24 kDa based on SDS-PAGE
1) MBS686029, Lot # 5-130-111907
2) Mol Weight Standard
anti-APOE antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for APOE. It may not necessarily be applicable to this product.
 NCBI GI #    178853
 NCBI GeneID    348
 NCBI Accession #    AAB59397 [Other Products]
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 UniProt Secondary Accession #    Q9P2S4; B2RC15; C0JYY5 [Other Products]
 UniProt Related Accession #    P02649 [Other Products]
 Molecular Weight    36,154 Da [Similar Products]
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 NCBI Official Full Name    apolipoprotein E
 NCBI Official Synonym Full Names    apolipoprotein E
 NCBI Official Symbol    APOE [Similar Products]
 NCBI Official Synonym Symbols   
AD2; LPG; APO-E; LDLCQ5
[Similar Products]
 NCBI Protein Information    apolipoprotein E
 UniProt Protein Name    Apolipoprotein E
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOE [Similar Products]
 UniProt Synonym Gene Names    Apo-E [Similar Products]
 UniProt Entry Name    APOE_HUMAN
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 NCBI Summary for APOE    The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
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 UniProt Comments for APOE    APOE: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3); also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2). It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Defects in APOE are a cause of sea-blue histiocyte disease (SBHD); also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Defects in APOE are a cause of lipoprotein glomerulopathy (LPG). LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: Golgi apparatus; extracellular space; microtubule; lysosome; endoplasmic reticulum; dendrite; early endosome; extracellular region; nuclear envelope; extracellular matrix; chylomicron; extrinsic to external side of plasma membrane; membrane; cell soma; cytoplasm; late endosome; plasma membrane; nucleus; vesicle

Molecular Function: lipid transporter activity; heparin binding; identical protein binding; protein homodimerization activity; metal chelating activity; beta-amyloid binding; cholesterol binding; antioxidant activity; protein binding; low-density lipoprotein receptor binding; cholesterol transporter activity; hydroxyapatite binding; phospholipid binding; lipid binding; tau protein binding

Biological Process: phototransduction, visible light; lipoprotein catabolic process; negative regulation of MAP kinase activity; cGMP-mediated signaling; positive regulation of axon extension; axon regeneration in the peripheral nervous system; positive regulation of membrane protein ectodomain proteolysis; synaptic transmission, cholinergic; intracellular transport; triacylglycerol catabolic process; oligodendrocyte differentiation; negative regulation of neuron apoptosis; cholesterol catabolic process; long-chain fatty acid transport; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; positive regulation of nitric-oxide synthase activity; negative regulation of blood coagulation; lipoprotein metabolic process; positive regulation of lipid biosynthetic process; regulation of axon extension; negative regulation of blood vessel endothelial cell migration; maintenance of cellular localization; response to reactive oxygen species; cholesterol homeostasis; response to ethanol; positive regulation of cGMP biosynthetic process; regulation of gene expression; lipoprotein biosynthetic process; protein import; negative regulation of endothelial cell proliferation; nitric oxide mediated signal transduction; regulation of neuronal synaptic plasticity; response to dietary excess; vasodilation; response to insulin stimulus; positive regulation of low-density lipoprotein receptor catabolic process; phospholipid efflux; negative regulation of cholesterol biosynthetic process; retinoid metabolic process; aging; receptor-mediated endocytosis; response to retinoic acid; negative regulation of lipid biosynthetic process; neurite regeneration; cholesterol efflux; cytoskeleton organization and biogenesis; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; triacylglycerol metabolic process; reverse cholesterol transport; negative regulation of inflammatory response; fatty acid homeostasis; artery morphogenesis

Disease: Macular Degeneration, Age-related, 1; Alzheimer Disease 2; Alzheimer Disease 4; Lipoprotein Glomerulopathy; Sea-blue Histiocyte Disease
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 Research Articles on APOE    1. APOE SNP is significantly associated with late onset Alzheimer disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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