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anti-AurB/C antibody :: AurB/C Antibody

Scan QR to view Datasheet Catalog #    MBS853107
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AurB/C, Antibody

★Popular Item★
 Also Known As   

AurB/C (Phospho-Thr236/202) Antibody

 Product Synonym Names    AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 1; Aurora/Ipl1/Eg2 protein 2; EC 2.7.11.1; STK13; STKD; Serine/threonine protein kinase 13; kinase AIK3
 Product Gene Name   

anti-AurB/C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    243060
 3D Structure    ModBase 3D Structure for Q9UQB9
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    AurB/C (Phospho-Thr236/202) antibody detects endogenous levels of AurB/C only when phosphorylated at threonine 236/202.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 236/202 (C-G-TP-L-D).
 All Sites    Human: Thr236/202
Mouse: Thr241/175
Rat: Thr239/175
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-AurB/C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-AurB/C antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-AurB/C antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-AurB/C antibody    IHC: 1:50-1:100
ELISA: 1:10000
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 Testing Data of anti-AurB/C antibody    P-peptide-+
anti-AurB/C antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-AurB/C antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using AurB/C (Phospho-Thr236/202) antibody. AurB/C (Phospho-Thr236/202) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-AurB/C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AurB/C. It may not necessarily be applicable to this product.
 NCBI GI #    62865639
 NCBI GeneID    6795
 NCBI Accession #    NP_001015878.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001015878.1 [Other Products]
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 UniProt Primary Accession #    Q9UQB9 [Other Products]
 UniProt Secondary Accession #    O60681; O75442; Q6AZY8; Q6DLZ0; Q9UPK5 [Other Products]
 UniProt Related Accession #    Q9UQB9 [Other Products]
 Molecular Weight    33,672 Da
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 NCBI Official Full Name    aurora kinase C isoform 1
 NCBI Official Synonym Full Names    aurora kinase C
 NCBI Official Symbol    AURKC [Similar Products]
 NCBI Official Synonym Symbols   
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
[Similar Products]
 NCBI Protein Information    aurora kinase C
 UniProt Protein Name    Aurora kinase C
 UniProt Synonym Protein Names   
Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
 UniProt Gene Name    AURKC [Similar Products]
 UniProt Synonym Gene Names    AIE2; AIK3; AIRK3; ARK3; STK13; ARK-3; Aurora-related kinase 3 [Similar Products]
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 NCBI Summary for AurB/C    This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AurB/C    Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
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Product References and Citations for anti-AurB/C antibody

   Steven L. Warner. Mol. Cancer Ther., Oct 2006; 5: 2450-2458. Adrianne E. Hontz. AACR Meeting Abstracts, Apr 2005; 2005: 492. Adrianne E. Hontz. AACR Meeting Abstracts, Apr 2006; 2006: 1326.
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 Research Articles on AurB/C    1. Identification and characterization of AURKB and AURKC variants associated with maternal aneuploidy has been reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AurB/C antibodyPathways associated with anti-AurB/C antibody
 Reference Product  PubMed Publications
 AURKB antibody  >7 publications with AurB/C and AURKB
 CEBPD antibody  >1 publications with AurB/C and CEBPD
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Aurora C Signaling Pathway antibodies  Aurora C Signaling Pathway Diagram
 Signaling By Aurora Kinases Pathway antibodies  Signaling By Aurora Kinases Pathway Diagram
Diseases associated with anti-AurB/C antibodyOrgans/Tissues associated with anti-AurB/C antibody
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >7 publications with AurB/C and Infertility, Male
 Infertility, Female Antibodies  >3 publications with AurB/C and Infertility, Female
 Neoplasms Antibodies  >3 publications with AurB/C and Neoplasms
 Abnormalities, Multiple Antibodies  >2 publications with AurB/C and Abnormalities, Multiple
 Necrosis Antibodies  >2 publications with AurB/C and Necrosis
 Inflammation Antibodies  >1 publications with AurB/C and Inflammation
 Embryo Loss Antibodies  >1 publications with AurB/C and Embryo Loss
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with AurB/C and Testis
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