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anti-AurB/C antibody :: Rabbit AurB/C Antibody

Scan QR to view Datasheet Catalog #    MBS853107
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AurB/C, Antibody

★Popular Item★
 Also Known As   

AurB/C (Phospho-Thr236/202) Antibody

 Product Synonym Names    AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 1; Aurora/Ipl1/Eg2 protein 2; EC 2.7.11.1; STK13; STKD; Serine/threonine protein kinase 13; kinase AIK3
 Product Gene Name   

anti-AurB/C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604970
 3D Structure    ModBase 3D Structure for Q96GD4
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    AurB/C (Phospho-Thr236/202) antibody detects endogenous levels of AurB/C only when phosphorylated at threonine 236/202.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 236/202 (C-G-TP-L-D).
 All Sites    Human: Thr236/202; Mouse: Thr241/175; Rat: Thr239/175
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-AurB/C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-AurB/C antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-AurB/C antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-AurB/C antibody    IHC: 1:50~1:100, ELISA: 1:10000
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 Testing Data of anti-AurB/C antibody    P-peptide - +
anti-AurB/C antibody Testing Data image
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 Testing Data #2 of anti-AurB/C antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using AurB/C (Phospho-Thr236/202) antibody.
AurB/C (Phospho-Thr236/202) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-AurB/C antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for AurB/C. It may not necessarily be applicable to this product.
 NCBI GI #    378786658
 NCBI GeneID    9212
 NCBI Accession #    NP_001243763.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256834.1 [Other Products]
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 UniProt Primary Accession #    Q96GD4 [Other Products]
 UniProt Secondary Accession #    O14630; O60446; O95083; Q96DV5; Q9UQ46; B4DNM4; C7G533; C7G534; C7G535; D3DTR4; J9JID1 [Other Products]
 UniProt Related Accession #    Q96GD4 [Other Products]
 Molecular Weight    39,467 Da
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 NCBI Official Full Name    aurora kinase B isoform 2
 NCBI Official Synonym Full Names    aurora kinase B
 NCBI Official Symbol    AURKB [Similar Products]
 NCBI Official Synonym Symbols   
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
[Similar Products]
 NCBI Protein Information    aurora kinase B; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1
 UniProt Protein Name    Aurora kinase B
 UniProt Synonym Protein Names   
Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B
 UniProt Gene Name    AURKB [Similar Products]
 UniProt Synonym Gene Names    AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; AIM-1; ARK-2; Aurora-related kinase 2 [Similar Products]
 UniProt Entry Name    AURKB_HUMAN
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 NCBI Summary for AurB/C    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
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 UniProt Comments for AurB/C    AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: spindle microtubule; spindle; spindle midzone; midbody; spindle pole centrosome; cytosol; nucleus; condensed nuclear chromosome, pericentric region; chromocenter

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; ATP binding

Biological Process: positive regulation of cytokinesis; spindle stabilization; spindle checkpoint; spindle midzone assembly involved in mitosis; protein amino acid autophosphorylation; regulation of chromosome segregation; negative regulation of transcription from RNA polymerase II promoter; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation; negative regulation of cytokinesis; cell proliferation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; abscission; histone modification; mitotic cell cycle; negative regulation of protein binding; negative regulation of B cell apoptosis; aging
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Product References and Citations for anti-AurB/C antibody

   Steven L. Warner. Mol. Cancer Ther., Oct 2006; 5: 2450 - 2458.
Adrianne E. Hontz. AACR Meeting Abstracts, Apr 2005; 2005: 492.
Adrianne E. Hontz. AACR Meeting Abstracts, Apr 2006; 2006: 1326.
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 Research Articles on AurB/C    1. Aberrant expression of Aurora-C displaces the centromeric location of Aurora-B.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AurB/C antibodyPathways associated with anti-AurB/C antibody
 Reference Product  PubMed Publications
 INCENP antibody  >91 publications with AurB/C and INCENP
 BIRC5 antibody  >82 publications with AurB/C and BIRC5
 NDC80 antibody  >23 publications with AurB/C and NDC80
 CDCA8 antibody  >23 publications with AurB/C and CDCA8
 CDC20 antibody  >12 publications with AurB/C and CDC20
 BUB1B antibody  >10 publications with AurB/C and BUB1B
 KIF23 antibody  >9 publications with AurB/C and KIF23
 KIF20A antibody  >4 publications with AurB/C and KIF20A
 CENPA antibody  >4 publications with AurB/C and CENPA
 RACGAP1 antibody  >1 publications with AurB/C and RACGAP1
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Aurora C Signaling Pathway antibodies  Aurora C Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
Diseases associated with anti-AurB/C antibodyOrgans/Tissues associated with anti-AurB/C antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >28 publications with AurB/C and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >28 publications with AurB/C and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >20 publications with AurB/C and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >20 publications with AurB/C and Lung Neoplasms
 Nervous System Diseases Antibodies  >18 publications with AurB/C and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >14 publications with AurB/C and Neoplasm Metastasis
 Pancreatic Neoplasms Antibodies  >13 publications with AurB/C and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >13 publications with AurB/C and Disease Models, Animal
 Liver Neoplasms Antibodies  >11 publications with AurB/C and Liver Neoplasms
 Prostatic Neoplasms Antibodies  >11 publications with AurB/C and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with AurB/C and Blood
 Lung Antibodies  >26 publications with AurB/C and Lung
 Liver Antibodies  >21 publications with AurB/C and Liver
 Brain Antibodies  >20 publications with AurB/C and Brain
 Prostate Antibodies  >17 publications with AurB/C and Prostate
 Bone Antibodies  >15 publications with AurB/C and Bone
 Bone Marrow Antibodies  >12 publications with AurB/C and Bone Marrow
 Testis Antibodies  >11 publications with AurB/C and Testis
 Lymph Antibodies  >11 publications with AurB/C and Lymph
 Lymph Node Antibodies  >11 publications with AurB/C and Lymph Node
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