Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow B-Raf  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • DGKB Antibody
 • BRP44 Antibody
 • ATF1 (Ab-63) Antibody
 • VN1R2 Antibody
 • Signal Transducer and Activator of Transcription 5A (STAT5A) ELISA Kit
 • Prostaglandin E Synthase, Microsomal (PTGES) ELISA Kit
 • Bone Morphogenetic Protein 4 (BMP4) ELISA Kit
 • 3 Carboxyl 4 Methyl 5 Propyl 2 Furangroup (CMPF) ELISA Kit
 • Nucleoporin 85Kda (NUP85) ELISA Kit
 • Cholecystokinin B Receptor (CCKBR) ELISA Kit
 • Abnormal Prothrombin (APT) ELISA Kit
 • Steroidogenic Acute Regulatory Protein (STAR) ELISA Kit
 • Integrin alpha6 (ITGalpha6) ELISA Kit
 • Vitamin A (VA) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-B-Raf antibody :: Rabbit B-Raf (Phospho-Thr753) Antibody

Scan QR to view Datasheet Catalog #    MBS002460 anti-B-Raf antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-Raf (Phospho-Thr753), Antibody

 Also Known As   

Rabbit B-Raf (Phospho-Thr753) Antibody

 Product Gene Name   

anti-B-Raf antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 7; NC_000007.13 (140433812..140624564, complement). Location: 7q34
 OMIM    114500
 3D Structure    ModBase 3D Structure for P15056
Section Bar
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
Section Bar
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
Section Bar
 Other Notes    Small volumes of anti-B-Raf antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-B-Raf antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for B-Raf. It may not necessarily be applicable to this product.
 NCBI GI #    33188459
 NCBI GeneID    673
 NCBI Accession #    NP_004324.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004333.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P15056 [Other Products]
 UniProt Secondary Accession #    Q13878; Q3MIN6; Q9UDP8; Q9Y6T3; A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66 [Other Products]
 UniProt Related Accession #    P15056 [Other Products]
 Molecular Weight    84,437 Da
Table BarTOPTable Bar
 NCBI Official Full Name    serine/threonine-protein kinase B-raf
 NCBI Official Synonym Full Names    v-raf murine sarcoma viral oncogene homolog B1
 NCBI Official Symbol    BRAF [Similar Products]
 NCBI Official Synonym Symbols   
NS7; BRAF1; RAFB1; B-RAF1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase B-raf; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p94)
 UniProt Protein Name    Serine/threonine-protein kinase B-raf
 UniProt Synonym Protein Names   
Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
 UniProt Gene Name    BRAF [Similar Products]
 UniProt Synonym Gene Names    BRAF1; RAFB1 [Similar Products]
 UniProt Entry Name    BRAF_HUMAN
Section Bar
 NCBI Summary for B-Raf    This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for B-Raf    BRAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.

Protein type: Oncoprotein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; RAF family

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: neuron projection; mitochondrion; plasma membrane; nucleus; cytosol

Molecular Function: small GTPase binding; identical protein binding; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; protein heterodimerization activity; mitogen-activated protein kinase kinase binding; calcium ion binding; ATP binding; protein kinase activity

Biological Process: positive T cell selection; response to peptide hormone stimulus; response to cAMP; fibroblast growth factor receptor signaling pathway; CD4-positive, alpha beta T cell differentiation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein heterooligomerization; somatic stem cell maintenance; MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; synaptic transmission; organ morphogenesis; myeloid progenitor cell differentiation; small GTPase mediated signal transduction; positive regulation of stress fiber formation; visual learning; negative regulation of neuron apoptosis; negative regulation of apoptosis

Disease: Noonan Syndrome 1; Noonan Syndrome 7; Lung Cancer; Leopard Syndrome 3; Cardiofaciocutaneous Syndrome 1
Table BarTOPTable Bar
 Research Articles on B-Raf    1. The novel melanoma cell lines were compared to metastatic cell lines (HBL, LND1), wild type (wt) for MC1R and BRAF genes.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-B-Raf antibodyPathways associated with anti-B-Raf antibody
 Reference Product  PubMed Publications
 HRAS antibody  >129 publications with B-Raf and HRAS
 MAP2K1 antibody  >89 publications with B-Raf and MAP2K1
 MAPK1 antibody  >66 publications with B-Raf and MAPK1
 MAP2K2 antibody  >55 publications with B-Raf and MAP2K2
 AKT1 antibody  >55 publications with B-Raf and AKT1
 RAF1 antibody  >45 publications with B-Raf and RAF1
 RHEB antibody  >5 publications with B-Raf and RHEB
 RAP1GAP antibody  >2 publications with B-Raf and RAP1GAP
 RAP1A antibody  >1 publications with B-Raf and RAP1A
 MRAS antibody  >1 publications with B-Raf and MRAS
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
Diseases associated with anti-B-Raf antibodyOrgans/Tissues associated with anti-B-Raf antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3016 publications with B-Raf and Neoplasms
 Carcinoma Antibodies  >1226 publications with B-Raf and Carcinoma
 Melanoma Antibodies  >1214 publications with B-Raf and Melanoma
 Neuroendocrine Tumors Antibodies  >892 publications with B-Raf and Neuroendocrine Tumors
 Colorectal Neoplasms Antibodies  >821 publications with B-Raf and Colorectal Neoplasms
 Thyroid Neoplasms Antibodies  >667 publications with B-Raf and Thyroid Neoplasms
 Skin Neoplasms Antibodies  >456 publications with B-Raf and Skin Neoplasms
 Neoplasm Metastasis Antibodies  >327 publications with B-Raf and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >176 publications with B-Raf and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >167 publications with B-Raf and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >806 publications with B-Raf and Thyroid
 Skin Antibodies  >577 publications with B-Raf and Skin
 Lymph Node Antibodies  >233 publications with B-Raf and Lymph Node
 Lung Antibodies  >231 publications with B-Raf and Lung
 Blood Antibodies  >224 publications with B-Raf and Blood
 Brain Antibodies  >173 publications with B-Raf and Brain
 Kidney Antibodies  >67 publications with B-Raf and Kidney
 Prostate Antibodies  >43 publications with B-Raf and Prostate
 Ovary Antibodies  >34 publications with B-Raf and Ovary
 Pancreas Antibodies  >28 publications with B-Raf and Pancreas
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions