NP_031548.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
22,080 Da
NCBI Official Full Name
bcl2 antagonist of cell death
NCBI Official Synonym Full Names
BCL2-associated agonist of cell death
NCBI Protein Information
bcl2 antagonist of cell death; bcl-2-binding component 6; Bcl-associated death promoter; bcl-xL/Bcl-2-associated death promoter
UniProt Protein Name
Bcl2 antagonist of cell death
UniProt Synonym Protein Names
Bcl-2-binding component 6; Bcl-xL/Bcl-2-associated death promoter
UniProt Synonym Gene Names
UniProt Entry Name
BAD_MOUSE
UniProt Comments for BAD
BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL.
Protein type: Apoptosis
Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; intracellular; cytosol
Molecular Function: protein kinase B binding; protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; protein phosphatase binding; lipid binding; protein kinase binding; protein phosphatase 2B binding
Biological Process: apoptosis; positive regulation of proteolysis; positive regulation of apoptosis; positive regulation of caspase activity; regulation of caspase activity; cellular process regulating host cell cycle in response to virus; glucose homeostasis; positive regulation of apoptosis by virus; regulation of apoptosis; pore complex biogenesis; positive regulation of glucokinase activity; caspase activation; release of cytochrome c from mitochondria; cytokine and chemokine mediated signaling pathway; suppression by virus of host apoptosis; ADP metabolic process; positive regulation of insulin secretion; ATP metabolic process; cell proliferation; glucose catabolic process; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of T cell differentiation; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; positive regulation of epithelial cell proliferation
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Disclaimer
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Products associated with anti-BAD antibody
Pathways associated with anti-BAD antibody
Diseases associated with anti-BAD antibody
Organs/Tissues associated with anti-BAD antibody
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