NP_061330.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,883 Da
NCBI Official Full Name
brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
NCBI Official Synonym Full Names
BAI1-associated protein 2-like 1
NCBI Official Synonym Symbols
NCBI Protein Information
brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate
UniProt Protein Name
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
UniProt Synonym Protein Names
Insulin receptor tyrosine kinase substrate
UniProt Synonym Gene Names
UniProt Entry Name
BI2L1_HUMAN
NCBI Summary for BAIAP2L1
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
UniProt Comments for BAIAP2L1
IRTKS: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; actin cytoskeleton
Molecular Function: protein binding; actin binding
Biological Process: regulation of insulin receptor signaling pathway; response to bacterium; plasma membrane organization and biogenesis; positive regulation of actin filament polymerization
Research Articles on BAIAP2L1
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Diseases associated with anti-BAIAP2L1 antibody
Organs/Tissues associated with anti-BAIAP2L1 antibody
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