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anti-BATF antibody :: anti-Human, Mouse BATF Antibody

Scan QR to view Datasheet Catalog #    MBS855740
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BATF, Antibody

★Popular Item★
 Also Known As   

BATF Antibody

 Product Synonym Names    B-ATF; SF-HT-activated gene 2 protein; SFA-2
 Product Gene Name   

anti-BATF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612476
 3D Structure    ModBase 3D Structure for Q16520
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 Species Reactivity    Human, Mouse
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 Specificity    BATF antibody detects endogenous levels of total BATF protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human BATF.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-BATF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-BATF antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-BATF antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-BATF antibody    IHC: 1:50-1:100
ELISA: 1:1000
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 Immunohistochemistry (IHC) of anti-BATF antibody    Peptide-+ Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BATF antibody.
anti-BATF antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BATF. It may not necessarily be applicable to this product.
 NCBI GI #    5453563
 NCBI GeneID    10538
 NCBI Accession #    NP_006390.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006399.3 [Other Products]
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 UniProt Primary Accession #    Q16520 [Other Products]
 UniProt Related Accession #    Q16520 [Other Products]
 Molecular Weight    14,120 Da
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 NCBI Official Full Name    basic leucine zipper transcriptional factor ATF-like
 NCBI Official Synonym Full Names    basic leucine zipper ATF-like transcription factor
 NCBI Official Symbol    BATF [Similar Products]
 NCBI Official Synonym Symbols   
SFA2; B-ATF; BATF1; SFA-2
[Similar Products]
 NCBI Protein Information    basic leucine zipper transcriptional factor ATF-like
 UniProt Protein Name    Basic leucine zipper transcriptional factor ATF-like
 UniProt Synonym Protein Names   
B-cell-activating transcription factor; B-ATF; SF-HT-activated gene 2 protein; SFA-2
 Protein Family    Basic leucine zipper transcriptional factor
 UniProt Gene Name    BATF [Similar Products]
 UniProt Synonym Gene Names    B-ATF; SFA-2 [Similar Products]
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 NCBI Summary for BATF    The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BATF    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs ().
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Product References and Citations for anti-BATF antibody

   Dorsey M.J., Oncogene 11:2255-2265(1995). Hasegawa H., Biochem. Biophys. Res. Commun. 222:164-170(1996). Meyer N.P., Mamm. Genome 9:849-852(1998).
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 Research Articles on BATF    1. BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. Apart from that we suggest an important function in mast cell development and in murine models of allergic asthma, it was observed that mice deficient for Batf are protected from the disease. Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BATF antibodyDiseases associated with anti-BATF antibody
 Reference Product  PubMed Publications
 JUN antibody  >17 publications with BATF and JUN
 FOS antibody  >10 publications with BATF and FOS
 JUND antibody  >1 publications with BATF and JUND
 JUNB antibody  >1 publications with BATF and JUNB
 IFI35 antibody  >1 publications with BATF and IFI35
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with BATF and Neoplasms
 Inflammation Antibodies  >8 publications with BATF and Inflammation
 Disease Models, Animal Antibodies  >5 publications with BATF and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >3 publications with BATF and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >2 publications with BATF and Brain Diseases
 Atherosclerosis Antibodies  >1 publications with BATF and Atherosclerosis
 Liver Neoplasms Antibodies  >1 publications with BATF and Liver Neoplasms
 Arteriosclerosis Antibodies  >1 publications with BATF and Arteriosclerosis
 Liver Neoplasms, Experimental Antibodies  >1 publications with BATF and Liver Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with BATF and Liver Diseases
Organs/Tissues associated with anti-BATF antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with BATF and Blood
 Lymph Node Antibodies  >5 publications with BATF and Lymph Node
 Lymph Antibodies  >3 publications with BATF and Lymph
 Lung Antibodies  >3 publications with BATF and Lung
 Vascular Antibodies  >2 publications with BATF and Vascular
 Intestine Antibodies  >1 publications with BATF and Intestine
 Skin Antibodies  >1 publications with BATF and Skin
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