NP_001248337.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
82,357 Da
NCBI Official Full Name
breast cancer anti-estrogen resistance protein 3 isoform 1
NCBI Official Synonym Full Names
BCAR3, NSP family adaptor protein
NCBI Protein Information
breast cancer anti-estrogen resistance protein 3
UniProt Protein Name
Breast cancer anti-estrogen resistance protein 3
UniProt Synonym Protein Names
Novel SH2-containing protein 2; SH2 domain-containing protein 3B
UniProt Synonym Gene Names
NCBI Summary for BCAR3
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
UniProt Comments for BCAR3
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.
Product References and Citations for anti-BCAR3 antibody
van Agthoven T., EMBO J. 17:2799-2808(1998). Lu Y., J. Biol. Chem. 274:10047-10052(1999). Clark H.F., Genome Res. 13:2265-2270(2003).
Research Articles on BCAR3
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Products associated with anti-BCAR3 antibody
Pathways associated with anti-BCAR3 antibody
Diseases associated with anti-BCAR3 antibody
Organs/Tissues associated with anti-BCAR3 antibody
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