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anti-BCL-10 antibody :: Mouse anti-Human, Mouse BCL-10 Antibody

Scan QR to view Datasheet Catalog #    MBS850837
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL-10, Antibody

★Popular Item★
 Also Known As   

BCL-10 Antibody

 Product Synonym Names    CLAP; Me10; CIPER; c-E10; CARMEN
 Product Gene Name   

anti-BCL-10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137245
 3D Structure    ModBase 3D Structure for O95999
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 Isotype    IgG1
 Clone Number    4F8
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Form/Format    Purified antibody in PBS containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human BCL-10 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-BCL-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BCL-10 antibody

   Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
 Product Categories/Family for anti-BCL-10 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-BCL-10 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-BCL-10 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
FCM: 1:200-1:400
ELISA: 1:10000
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 Western Blot (WB) of anti-BCL-10 antibody    Figure 1. Western blot analysis using BCL10 mouse mAb against NIH/3T3 (1), Hela (2), MCF-7 (3) and Jurka (4) cell lysate
anti-BCL-10 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BCL-10 antibody    Figure 2. Immunohistochemical analysis ofparaffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10mouse mAb with DAB staining.
anti-BCL-10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-BCL-10 antibody    Figure 3.Confocal immunofluorescence analysis of Hela (left) and NTERA-2 (right) cells using NPM mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.
anti-BCL-10 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for BCL-10. It may not necessarily be applicable to this product.
 NCBI GI #    4502379
 NCBI GeneID    8915
 NCBI Accession #    NP_003912.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003921.5 [Other Products]
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 UniProt Primary Accession #    O95999 [Other Products]
 UniProt Secondary Accession #    Q5VUF1 [Other Products]
 UniProt Related Accession #    O95999 [Other Products]
 Molecular Weight    26kDa
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 NCBI Official Full Name    B-cell lymphoma/leukemia 10 isoform 1
 NCBI Official Synonym Full Names    B cell CLL/lymphoma 10
 NCBI Official Symbol    BCL10 [Similar Products]
 NCBI Official Synonym Symbols   
CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
[Similar Products]
 NCBI Protein Information    B-cell lymphoma/leukemia 10
 UniProt Protein Name    B-cell lymphoma/leukemia 10
 UniProt Synonym Protein Names   
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10
 UniProt Gene Name    BCL10 [Similar Products]
 UniProt Synonym Gene Names    CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10 [Similar Products]
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 NCBI Summary for BCL-10    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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 UniProt Comments for BCL-10    Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
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 Research Articles on BCL-10    1. results define molecular determinants that control the production of Lin(Ub)n-Bcl10, an important signaling intermediate in TCR and oncogenic CARD11 signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL-10 antibodyPathways associated with anti-BCL-10 antibody
 Reference Product  PubMed Publications
 MALT1 antibody  >195 publications with BCL-10 and MALT1
 CARD11 antibody  >77 publications with BCL-10 and CARD11
 CARD9 antibody  >25 publications with BCL-10 and CARD9
 CHUK antibody  >18 publications with BCL-10 and CHUK
 CARD10 antibody  >17 publications with BCL-10 and CARD10
 TRAF2 antibody  >12 publications with BCL-10 and TRAF2
 TLR4 antibody  >11 publications with BCL-10 and TLR4
 CASP9 antibody  >8 publications with BCL-10 and CASP9
 IKBKG antibody  >5 publications with BCL-10 and IKBKG
 CARD14 antibody  >5 publications with BCL-10 and CARD14
 Products by Pathway  Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-BCL-10 antibodyOrgans/Tissues associated with anti-BCL-10 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >233 publications with BCL-10 and Neoplasms
 Immune System Diseases Antibodies  >186 publications with BCL-10 and Immune System Diseases
 Necrosis Antibodies  >33 publications with BCL-10 and Necrosis
 Inflammation Antibodies  >31 publications with BCL-10 and Inflammation
 Lung Diseases Antibodies  >11 publications with BCL-10 and Lung Diseases
 Cardiovascular Diseases Antibodies  >9 publications with BCL-10 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >7 publications with BCL-10 and Nervous System Diseases
 Liver Diseases Antibodies  >7 publications with BCL-10 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with BCL-10 and Kidney Diseases
 Liver Neoplasms Antibodies  >5 publications with BCL-10 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >117 publications with BCL-10 and Blood
 Stomach Antibodies  >40 publications with BCL-10 and Stomach
 Intestine Antibodies  >16 publications with BCL-10 and Intestine
 Lung Antibodies  >16 publications with BCL-10 and Lung
 Lymph Node Antibodies  >15 publications with BCL-10 and Lymph Node
 Liver Antibodies  >14 publications with BCL-10 and Liver
 Nerve Antibodies  >11 publications with BCL-10 and Nerve
 Skin Antibodies  >10 publications with BCL-10 and Skin
 Bone Antibodies  >10 publications with BCL-10 and Bone
 Spleen Antibodies  >10 publications with BCL-10 and Spleen
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