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anti-BCL-XL antibody :: Rabbit BCL-XL (Ab-47) Antibody

Scan QR to view Datasheet Catalog #    MBS004758 anti-BCL-XL antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL-XL (Ab-47), Antibody

 Also Known As   

Rabbit BCL-XL (Ab-47) Antibody

 Product Gene Name   

anti-BCL-XL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (30252261..30310656, complement). Location: 20q11.21
 OMIM    600039
 3D Structure    ModBase 3D Structure for Q07817
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-BCL-XL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BCL-XL antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for BCL-XL. It may not necessarily be applicable to this product.
 NCBI GI #    4502381
 NCBI GeneID    598
 NCBI Accession #    NP_001182.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001191.2 [Other Products]
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 UniProt Primary Accession #    Q07817 [Other Products]
 UniProt Secondary Accession #    Q5CZ89; Q5TE65; Q92976; E1P5L6 [Other Products]
 UniProt Related Accession #    Q07817 [Other Products]
 Molecular Weight    26,049 Da
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 NCBI Official Full Name    bcl-2-like protein 1 isoform 2
 NCBI Official Synonym Full Names    BCL2-like 1
 NCBI Official Symbol    BCL2L1 [Similar Products]
 NCBI Official Synonym Symbols   
BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S
[Similar Products]
 NCBI Protein Information    bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52
 UniProt Protein Name    Bcl-2-like protein 1
 UniProt Synonym Protein Names   
Apoptosis regulator Bcl-X
 UniProt Gene Name    BCL2L1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L; BCLX; Bcl2-L-1 [Similar Products]
 UniProt Entry Name    B2CL1_HUMAN
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 NCBI Summary for BCL-XL    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BCL-XL    Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.

Protein type: Autophagy; Apoptosis; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: centrosome; nuclear membrane; synaptic vesicle membrane; mitochondrion; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; nucleolus; cell junction; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding

Biological Process: negative regulation of autophagy; apoptosis; cytokinesis; cellular process regulating host cell cycle in response to virus; germ cell development; apoptotic mitochondrial changes; ovarian follicle development; regulation of mitochondrial membrane potential; positive regulation of cell proliferation; negative regulation of neuron apoptosis; release of cytochrome c from mitochondria; in utero embryonic development; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; endocytosis; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; innate immune response; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; negative regulation of apoptosis; growth
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 Research Articles on BCL-XL    1. Here, we report the docking studies that resulted in the identification of new inhibitors distinct from the previously reported inhibitor against Bcl-xL protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL-XL antibodyPathways associated with anti-BCL-XL antibody
 Reference Product  PubMed Publications
 BAX antibody  >2096 publications with BCL-XL and BAX
 BAD antibody  >533 publications with BCL-XL and BAD
 CASP9 antibody  >511 publications with BCL-XL and CASP9
 CASP8 antibody  >465 publications with BCL-XL and CASP8
 BID antibody  >326 publications with BCL-XL and BID
 BAK1 antibody  >226 publications with BCL-XL and BAK1
 CASP1 antibody  >84 publications with BCL-XL and CASP1
 CFLAR antibody  >71 publications with BCL-XL and CFLAR
 APAF1 antibody  >54 publications with BCL-XL and APAF1
 TP53 antibody  >53 publications with BCL-XL and TP53
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-BCL-XL antibodyOrgans/Tissues associated with anti-BCL-XL antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2372 publications with BCL-XL and Neoplasms
 Carcinoma Antibodies  >793 publications with BCL-XL and Carcinoma
 Necrosis Antibodies  >629 publications with BCL-XL and Necrosis
 Nervous System Diseases Antibodies  >357 publications with BCL-XL and Nervous System Diseases
 Drug Toxicity Antibodies  >352 publications with BCL-XL and Drug Toxicity
 Brain Diseases Antibodies  >277 publications with BCL-XL and Brain Diseases
 Gastrointestinal Diseases Antibodies  >274 publications with BCL-XL and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >246 publications with BCL-XL and Breast Neoplasms
 Liver Diseases Antibodies  >236 publications with BCL-XL and Liver Diseases
 Neoplasms, Experimental Antibodies  >224 publications with BCL-XL and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1261 publications with BCL-XL and Blood
 Brain Antibodies  >518 publications with BCL-XL and Brain
 Liver Antibodies  >404 publications with BCL-XL and Liver
 Lung Antibodies  >271 publications with BCL-XL and Lung
 Vascular Antibodies  >254 publications with BCL-XL and Vascular
 Bone Antibodies  >249 publications with BCL-XL and Bone
 Muscle Antibodies  >228 publications with BCL-XL and Muscle
 Prostate Antibodies  >183 publications with BCL-XL and Prostate
 Heart Antibodies  >180 publications with BCL-XL and Heart
 Kidney Antibodies  >163 publications with BCL-XL and Kidney
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