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anti-BCL2 antibody :: Rabbit BCL2 Antibody

Scan QR to view Datasheet Catalog #    MBS8500158 anti-BCL2 antibody
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL2, Antibody

★Popular Item★
 Also Known As   

BCL2 Antibody

 Product Synonym Names    BCL2; Bcl-2; ONCOGENE B-CELL LEUKEMIA 2; Apoptosis regulator Bcl-2
 Product Gene Name   

anti-BCL2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151430
 3D Structure    ModBase 3D Structure for P10415
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human Bcl-2
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-BCL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BCL2 antibody

   Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release (1). It has been implicated in modulating mitochondrial calcium homeostasis and proton flux (2). Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74 and Ser87 (3). It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway, and that phosphorylation of Bcl-2 may be a marker for mitotic events (4, 5). Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes (6). Interleukin 3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions (7).
 Product Categories/Family for anti-BCL2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-BCL2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-BCL2 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
Western blot analysis of extracts of Jurkatcell line, using BCL2 antibody.Immunohistochemistry of paraffin-embedded Breast cancer using BCL2 Antibody.
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NCBI/Uniprot data below describe general gene information for BCL2. It may not necessarily be applicable to this product.
 NCBI GI #    72198189
 NCBI GeneID    596
 NCBI Accession #    NP_000624.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000633.2 [Other Products]
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 UniProt Primary Accession #    P10415 [Other Products]
 UniProt Secondary Accession #    P10416; Q13842; Q16197; C9JHD5 [Other Products]
 UniProt Related Accession #    P10415 [Other Products]
 Molecular Weight    26kDa
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 NCBI Official Full Name    apoptosis regulator Bcl-2 isoform alpha
 NCBI Official Synonym Full Names    BCL2, apoptosis regulator
 NCBI Official Symbol    BCL2 [Similar Products]
 NCBI Official Synonym Symbols   
Bcl-2; PPP1R50
[Similar Products]
 NCBI Protein Information    apoptosis regulator Bcl-2
 UniProt Protein Name    Apoptosis regulator Bcl-2
 Protein Family    Bcl2-associated agonist of cell death
 UniProt Gene Name    BCL2 [Similar Products]
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 NCBI Summary for BCL2    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for BCL2    Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
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Product References and Citations for anti-BCL2 antibody

   1. Murphy, K.M. et al. (2000) Cell Death Differ 7, 102-11. 2. Zhu, L. et al. (1999) J Biol Chem 274, 33267-73. 3. Maundrell, K. et al. (1997) J Biol Chem 272, 25238-42. 4. Yamamoto, K. et al. (1999) Mol Cell Biol 19, 8469-78. 5. Ling, Y.H. et al. (1998) J Biol Chem 273, 18984-91. 6. Huang, S.T. and Cidlowski, J.A. (2002) FASEB J 16, 825-32. 7. Deng, X. et al. (2001) J Biol Chem 276, 23681-8.
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 Research Articles on BCL2    1. Bcl-2 high expression was significantly correlated with favorable overall survival and better disease/recurrence free survival in colorectal cancer.[meta-analysis]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL2 antibodyPathways associated with anti-BCL2 antibody
 Reference Product  PubMed Publications
 BAX antibody  >1023 publications with BCL2 and BAX
 CASP3 antibody  >536 publications with BCL2 and CASP3
 MYC antibody  >344 publications with BCL2 and MYC
 BAD antibody  >167 publications with BCL2 and BAD
 CASP8 antibody  >148 publications with BCL2 and CASP8
 TP53 antibody  >100 publications with BCL2 and TP53
 BID antibody  >91 publications with BCL2 and BID
 BNIP3 antibody  >57 publications with BCL2 and BNIP3
 BAK1 antibody  >55 publications with BCL2 and BAK1
 BAG1 antibody  >49 publications with BCL2 and BAG1
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with anti-BCL2 antibodyOrgans/Tissues associated with anti-BCL2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2172 publications with BCL2 and Neoplasms
 Lymphoma, Non-Hodgkin Antibodies  >614 publications with BCL2 and Lymphoma, Non-Hodgkin
 Carcinoma Antibodies  >541 publications with BCL2 and Carcinoma
 Lymphoma, Follicular Antibodies  >332 publications with BCL2 and Lymphoma, Follicular
 Necrosis Antibodies  >306 publications with BCL2 and Necrosis
 Lymphoma, Large B-Cell, Diffuse Antibodies  >298 publications with BCL2 and Lymphoma, Large B-Cell, Diffuse
 Breast Neoplasms Antibodies  >272 publications with BCL2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >210 publications with BCL2 and Adenocarcinoma
 Drug Toxicity Antibodies  >203 publications with BCL2 and Drug Toxicity
 Disease Progression Antibodies  >194 publications with BCL2 and Disease Progression
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >825 publications with BCL2 and Blood
 Bone Antibodies  >283 publications with BCL2 and Bone
 Brain Antibodies  >266 publications with BCL2 and Brain
 Muscle Antibodies  >227 publications with BCL2 and Muscle
 Lymph Node Antibodies  >216 publications with BCL2 and Lymph Node
 Bone Marrow Antibodies  >206 publications with BCL2 and Bone Marrow
 Lung Antibodies  >204 publications with BCL2 and Lung
 Lymph Antibodies  >174 publications with BCL2 and Lymph
 Vascular Antibodies  >166 publications with BCL2 and Vascular
 Heart Antibodies  >159 publications with BCL2 and Heart
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