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anti-BCL2 antibody :: Rabbit BCL2 Antibody

Scan QR to view Datasheet Catalog #    MBS8500158 anti-BCL2 antibody
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL2, Antibody

★Popular Item★
 Also Known As   

BCL2 Antibody

 Product Synonym Names    BCL2; Bcl-2 ; ONCOGENE B-CELL LEUKEMIA 2; Apoptosis regulator Bcl-2
 Product Gene Name   

anti-BCL2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P104153
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Immunogen    Recombinant protein of human Bcl-2
 Species    Rabbit
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 Preparation and Storage    Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-BCL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BCL2 antibody

   Background: Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release (1). It has been implicated in modulating mitochondrial calcium homeostasis and proton flux (2). Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74 and Ser87 (3). It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway, and that phosphorylation of Bcl-2 may be a marker for mitotic events (4,5). Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes (6). Interleukin 3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions (7).
 Product Categories/Family for anti-BCL2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-BCL2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-BCL2 antibody    Wb: 1:500-1:2000
IHC: 1:50-1:200
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NCBI/Uniprot data below describe general gene information for BCL2. It may not necessarily be applicable to this product.
 NCBI GeneID    596
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 UniProt Primary Accession #    P104153 [Other Products]
 UniProt Related Accession #    P10415 [Other Products]
 Molecular Weight    26kDa
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 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 2
 NCBI Official Symbol    BCL2 [Similar Products]
 NCBI Official Synonym Symbols   
Bcl-2; PPP1R50
[Similar Products]
 NCBI Protein Information    apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50
 Protein Family    Bcl2-associated agonist of cell death
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 NCBI Summary for BCL2    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BCL2    Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.

Protein type: Autophagy; Oncoprotein; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: pore complex; mitochondrial outer membrane; endoplasmic reticulum membrane; nuclear membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; cytosol; nucleus; myelin sheath

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; protein heterodimerization activity; channel activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding; channel inhibitor activity; transcription factor binding

Biological Process: positive regulation of catalytic activity; focal adhesion formation; response to nicotine; developmental growth; renal system process; protein polyubiquitination; pigment granule organization and biogenesis; response to toxin; response to glucocorticoid stimulus; T cell differentiation in the thymus; ear development; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; female pregnancy; glomerulus development; negative regulation of mitochondrial depolarization; post-embryonic development; cochlear nucleus development; cellular response to glucose starvation; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of mitochondrial membrane potential; negative regulation of ossification; positive regulation of B cell proliferation; regulation of transmembrane transporter activity; T cell homeostasis; negative regulation of neuron apoptosis; cell growth; defense response to virus; spleen development; response to drug; positive regulation of neuron maturation; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; axon regeneration; actin filament organization; cell aging; digestive tract morphogenesis; regulation of calcium ion transport; positive regulation of cell growth; organ growth; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of osteoblast proliferation; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; negative regulation of apoptosis; B cell proliferation; negative regulation of autophagy; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; apoptosis; negative regulation of retinal cell programmed cell death; regulation of cell-matrix adhesion; regulation of protein stability; protein amino acid dephosphorylation; positive regulation of smooth muscle cell migration; response to radiation; positive regulation of skeletal muscle fiber development; B cell homeostasis; ovarian follicle development; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; response to iron ion; negative regulation of cell migration; regulation of viral genome replication; transmembrane transport; negative regulation of cellular pH reduction; mesenchymal cell development; ossification; CD8-positive, alpha-beta T cell lineage commitment; hair follicle morphogenesis; thymus development; B cell lineage commitment; male gonad development; peptidyl-threonine phosphorylation; positive regulation of peptidyl-serine phosphorylation; humoral immune response; response to UV-B; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; neuron apoptosis; axonogenesis; response to hydrogen peroxide; homeostasis of number of cells within a tissue; ureteric bud branching; response to cytokine stimulus; innate immune response; negative regulation of cell growth; induction of apoptosis by oxidative stress; response to DNA damage stimulus
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Product References and Citations for anti-BCL2 antibody

   1. Murphy, K.M. et al. (2000) Cell Death Differ 7, 102-11. 2. Zhu, L. et al. (1999) J Biol Chem 274, 33267-73. 3. Maundrell, K. et al. (1997) J Biol Chem 272, 25238-42. 4. Yamamoto, K. et al. (1999) Mol Cell Biol 19, 8469-78. 5. Ling, Y.H. et al. (1998) J Biol Chem 273, 18984-91. 6. Huang, S.T. and Cidlowski, J.A. (2002) FASEB J 16, 825-32. 7. Deng, X. et al. (2001) J Biol Chem 276, 23681-8.
WB 1:500 - 1:2000
IHC 1:50- 1:200
Western blot analysis of extracts of Jurkatcell line, using BCL2 antibody.Immunohistochemistry of paraffin-embedded Breast cancer using BCL2 Antibody.
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 Research Articles on BCL2    1. Silencing Bcl-2 in PTEN-mutated prostate cancer cells enhances the apoptotic effects of combined starvation and taxol treatments, indicating that inhibition of Bcl-2 may be of significant value in PTEN-mutant tumor therapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BCL2 antibody
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
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