NP_004450.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
322,217 Da
NCBI Official Full Name
nucleosome-remodeling factor subunit BPTF isoform 2
NCBI Official Synonym Full Names
bromodomain PHD finger transcription factor
NCBI Protein Information
nucleosome-remodeling factor subunit BPTF
UniProt Protein Name
Nucleosome-remodeling factor subunit BPTF
UniProt Synonym Protein Names
Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
UniProt Synonym Gene Names
NCBI Summary for BPTF
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
UniProt Comments for BPTF
FALZ: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Belongs to the PBTF family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; sequence-specific DNA binding; transcription factor binding
Biological Process: brain development; chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on BPTF
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Products associated with anti-BPTF antibody
Diseases associated with anti-BPTF antibody
Organs/Tissues associated with anti-BPTF antibody
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