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anti-BTK antibody :: Rabbit anti-Human, Mouse BTK Antibody

Scan QR to view Datasheet Catalog #    MBS852725
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BTK, Antibody

★Popular Item★
 Also Known As   

BTK (Ab-222) Antibody

 Product Synonym Names    AGMX1; ATK; Agammaglobulinaemia tyrosine kinase; B cell progenitor kinase; BPK; Bruton's tyrosine kinase; EC 2.7.10.2; Kinase EMB; kinase Btk
 Product Gene Name   

anti-BTK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    307200
 3D Structure    ModBase 3D Structure for Q06187
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    BTK (Ab-222) antibody detects endogenous levels of total BTK protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human BTK around the phosphorylation site of tyrosine 222 (A-L-YP-D-Y).
 Pathway    Phosphatases/Kinases
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-BTK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-BTK antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-BTK antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-BTK antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000
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 Testing Data of anti-BTK antibody    Peptide - +
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BTK (Ab-222) antibody (#B0054).
anti-BTK antibody Testing Data image
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 Testing Data #2 of anti-BTK antibody    Western blot analysis of extracts from Hela cells, using BTK (Ab-222) antibody (#B0054, Line 1 and 2).
anti-BTK antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for BTK. It may not necessarily be applicable to this product.
 NCBI GI #    4557377
 NCBI GeneID    695
 NCBI Accession #    NP_000052.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000061.2 [Other Products]
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 UniProt Primary Accession #    Q06187 [Other Products]
 UniProt Secondary Accession #    Q32ML5; B2RAW1 [Other Products]
 UniProt Related Accession #    Q06187 [Other Products]
 Molecular Weight    79,937 Da
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 NCBI Official Full Name    tyrosine-protein kinase BTK isoform 1
 NCBI Official Synonym Full Names    Bruton agammaglobulinemia tyrosine kinase
 NCBI Official Symbol    BTK [Similar Products]
 NCBI Official Synonym Symbols   
AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase BTK; B-cell progenitor kinase; agammaglobulinaemia tyrosine kinase; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK isoform (lacking exon 14); dominant-negative kinase-deficient Brutons tyrosine kinase
 UniProt Protein Name    Tyrosine-protein kinase BTK
 UniProt Synonym Protein Names   
Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    BTK [Similar Products]
 UniProt Synonym Gene Names    AGMX1; ATK; BPK; ATK; BPK [Similar Products]
 UniProt Entry Name    BTK_HUMAN
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 NCBI Summary for BTK    The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
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 UniProt Comments for BTK    Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: Xq21.33-q22

Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; lipid raft

Molecular Function: identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; protein-tyrosine kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; B cell activation; transcription, DNA-dependent; cell maturation; calcium-mediated signaling; protein amino acid phosphorylation; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; regulation of cell proliferation; MyD88-dependent toll-like receptor signaling pathway; regulation of B cell cytokine production; regulation of B cell apoptosis; B cell receptor signaling pathway; histamine secretion by mast cell; toll-like receptor signaling pathway; innate immune response; positive regulation of B cell differentiation; mesoderm development; cell differentiation; toll-like receptor 4 signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Isolated Growth Hormone Deficiency, Type Iii; Agammaglobulinemia, X-linked
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Product References and Citations for anti-BTK antibody

   Sulekha Verma, J. Biol. Chem., Feb 2001; 276: 4671 - 4676.
Yan M. Li, Cancer Res., Nov 2003; 63: 7630 - 7633.
Malti Nikrad, Mol. Cancer Ther., Mar 2005; 4: 443 - 449.
Feng Dong, Infect. Immun., Mar 2005; 73: 1861 - 1864.
Hiroo Ueno, Mol. Biol. Cell, Feb 2000; 11: 735.
Hidenori Hase, J. Biol. Chem., Nov 2002; 277: 46950 - 46958.
Yasuyuki Hirashima, J. Biol. Chem., Jul 2003; 278: 26793 - 26802.
Mingzhong Yao, J. Neurosci., Feb 2007; 27: 1422 - 1433.
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 Research Articles on BTK    1. We observed that Nef interacts with the Tec family members Bmx, Btk, and Itk but not Tec or Txk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BTK antibodyPathways associated with anti-BTK antibody
 Reference Product  PubMed Publications
 LYN antibody  >126 publications with BTK and LYN
 CD19 antibody  >42 publications with BTK and CD19
 BLNK antibody  >40 publications with BTK and BLNK
 CBL antibody  >16 publications with BTK and CBL
 MYD88 antibody  >15 publications with BTK and MYD88
 TIRAP antibody  >6 publications with BTK and TIRAP
 SH3BP5 antibody  >6 publications with BTK and SH3BP5
 GTF2I antibody  >5 publications with BTK and GTF2I
 PLCG2 antibody  >4 publications with BTK and PLCG2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-BTK antibodyOrgans/Tissues associated with anti-BTK antibody
 Disease Name  Pubmed Publications
 Agammaglobulinemia Antibodies  >789 publications with BTK and Agammaglobulinemia
 Inflammation Antibodies  >59 publications with BTK and Inflammation
 Cardiovascular Diseases Antibodies  >59 publications with BTK and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >42 publications with BTK and Disease Models, Animal
 Necrosis Antibodies  >37 publications with BTK and Necrosis
 Bruton type agammaglobulinemia Antibodies  >29 publications with BTK and Bruton type agammaglobulinemia
 Nervous System Diseases Antibodies  >22 publications with BTK and Nervous System Diseases
 Arteriosclerosis Antibodies  >15 publications with BTK and Arteriosclerosis
 Atherosclerosis Antibodies  >13 publications with BTK and Atherosclerosis
 Kidney Diseases Antibodies  >12 publications with BTK and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >675 publications with BTK and Blood
 Bone Antibodies  >129 publications with BTK and Bone
 Bone Marrow Antibodies  >115 publications with BTK and Bone Marrow
 Spleen Antibodies  >100 publications with BTK and Spleen
 Lung Antibodies  >30 publications with BTK and Lung
 Lymph Node Antibodies  >23 publications with BTK and Lymph Node
 Liver Antibodies  >23 publications with BTK and Liver
 Skin Antibodies  >21 publications with BTK and Skin
 Heart Antibodies  >19 publications with BTK and Heart
 Lymph Antibodies  >16 publications with BTK and Lymph
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