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anti-Bad antibody :: Rabbit Bad-S155 Antibody

Scan QR to view Datasheet Catalog #    MBS128522
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bad-S155, Antibody

 Also Known As   

Phospho-Bad-S155 Polyclonal Antibody

 Product Synonym Names    Phospho-Bad-S155: BBC2; BCL2L8
 Product Gene Name   

anti-Bad antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q61337
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A phospho specific peptide corresponding to residues surrounding S155 of human Bad
 Calculated Molecular Weight    23kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-Bad antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Bad antibody

   The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
 Product Categories/Family for anti-Bad antibody    Phosphorylation
 Applications Tested/Suitable for anti-Bad antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Bad antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
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 Western Blot (WB) of anti-Bad antibody    Western blot analysis of extracts from 293 cells using Phospho-Bad-S155 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
anti-Bad antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Bad antibody    Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-Bad-S155 antibody.
anti-Bad antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Bad. It may not necessarily be applicable to this product.
 NCBI GI #    2493288
 NCBI GeneID    12015
 NCBI Accession #    Q61337.1 [Other Products]
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 UniProt Primary Accession #    Q61337 [Other Products]
 UniProt Related Accession #    Q61337 [Other Products]
 Molecular Weight    168
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 NCBI Official Full Name    Bcl2-associated agonist of cell death
 NCBI Official Synonym Full Names    BCL2-associated agonist of cell death
 NCBI Official Symbol    Bad [Similar Products]
 NCBI Official Synonym Symbols   
Bbc2; AI325008
[Similar Products]
 NCBI Protein Information    bcl2-associated agonist of cell death; bcl-2-binding component 6; bcl2 antagonist of cell death; bcl-xL/Bcl-2-associated death promoter
 UniProt Protein Name    Bcl2-associated agonist of cell death
 UniProt Synonym Protein Names   
Bcl-2-binding component 6; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death
 Protein Family    Bcl2-associated agonist of cell death
 UniProt Gene Name    Bad [Similar Products]
 UniProt Synonym Gene Names    Bbc6; BAD [Similar Products]
 UniProt Entry Name    BAD_MOUSE
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 UniProt Comments for Bad    BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL.

Protein type: Apoptosis

Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; intracellular; cytosol

Molecular Function: protein kinase B binding; protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; protein kinase binding; protein phosphatase binding; lipid binding; protein phosphatase 2B binding

Biological Process: positive regulation of proteolysis; positive regulation of apoptosis; apoptosis; positive regulation of caspase activity; regulation of caspase activity; cellular process regulating host cell cycle in response to virus; glucose homeostasis; positive regulation of apoptosis by virus; regulation of apoptosis; pore complex biogenesis; positive regulation of glucokinase activity; caspase activation; release of cytochrome c from mitochondria; cytokine and chemokine mediated signaling pathway; suppression by virus of host apoptosis; positive regulation of insulin secretion; ADP metabolic process; ATP metabolic process; glucose catabolic process; cell proliferation; positive regulation of T cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; positive regulation of epithelial cell proliferation
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 Research Articles on Bad    1. Results indicate the downstream targets of insulin, cyclin D1, BAD, alpha-MHC, and GATA-4, elucidate a molecular mechanism of insulin in promoting cell proliferation and differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Bad antibodyDiseases associated with anti-Bad antibody
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4690 publications with Bad and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >3349 publications with Bad and Nervous System Diseases
 Heart Diseases Antibodies  >2748 publications with Bad and Heart Diseases
 Pain Antibodies  >1906 publications with Bad and Pain
 Brain Diseases Antibodies  >1623 publications with Bad and Brain Diseases
 Lung Diseases Antibodies  >1227 publications with Bad and Lung Diseases
 Inflammation Antibodies  >857 publications with Bad and Inflammation
 Hypertension Antibodies  >838 publications with Bad and Hypertension
 Necrosis Antibodies  >730 publications with Bad and Necrosis
 Liver Diseases Antibodies  >636 publications with Bad and Liver Diseases
Organs/Tissues associated with anti-Bad antibody
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >5330 publications with Bad and Other
 Heart Antibodies  >3455 publications with Bad and Heart
 Bone Antibodies  >1843 publications with Bad and Bone
 Brain Antibodies  >1834 publications with Bad and Brain
 Lung Antibodies  >1216 publications with Bad and Lung
 Joint Antibodies  >1103 publications with Bad and Joint
 Liver Antibodies  >976 publications with Bad and Liver
 Skin Antibodies  >825 publications with Bad and Skin
 Kidney Antibodies  >806 publications with Bad and Kidney
 Eye Antibodies  >494 publications with Bad and Eye
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