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anti-Bax antibody :: anti-Human, Mouse Bax Antibody

Scan QR to view Datasheet Catalog #    MBS853493
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bax, Antibody

 Also Known As   

Bax (Ab-167) Antibody

 Product Synonym Names    Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein
 Product Gene Name   

anti-Bax antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600040
 3D Structure    ModBase 3D Structure for Q07812
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 Species Reactivity    Human, Mouse
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 Specificity    Bax (Ab-167) antibody detects endogenous levels of total Bax protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human Bax around the phosphorylation site of threonine 167 (F-G-TP-P-T).
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-Bax antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Bax antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-Bax antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-Bax antibody    WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000
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 Testing Data of anti-Bax antibody    anti-Bax antibody Testing Data image
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 Western Blot (WB) of anti-Bax antibody    Peptide-+ Western blot analysis of extracts from HepG2 cells, using Bax (Ab-167) antibody. Immunofluorescence analysis of LOVO cells, using Bax (Ab-167) antibody.
anti-Bax antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Bax. It may not necessarily be applicable to this product.
 NCBI GI #    612149787
 NCBI GeneID    581
 NCBI Accession #    NP_001278357.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291428.1 [Other Products]
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 UniProt Primary Accession #    Q07812 [Other Products]
 UniProt Secondary Accession #    P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6; A8K4W1 [Other Products]
 UniProt Related Accession #    Q07812 [Other Products]
 Molecular Weight    19,718 Da
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 NCBI Official Full Name    apoptosis regulator BAX isoform 1
 NCBI Official Synonym Full Names    BCL2 associated X, apoptosis regulator
 NCBI Official Symbol    BAX [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    apoptosis regulator BAX
 UniProt Protein Name    Apoptosis regulator BAX
 UniProt Synonym Protein Names   
Bcl-2-like protein 4; Bcl2-L-4
 Protein Family    Bax inhibitor
 UniProt Gene Name    BAX [Similar Products]
 UniProt Synonym Gene Names    BCL2L4; Bcl2-L-4 [Similar Products]
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 NCBI Summary for Bax    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Bax    Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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Product References and Citations for anti-Bax antibody

   Oltvai Z.N., Cell 74:609-619(1993). Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001). Guo B., Nature 423:456-461(2003).
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 Research Articles on Bax    1. High mitochondrial Bax apoptosis regulator protein (BAX) levels correlate with improved acute myeloid leukemia (AML) patient survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Bax antibodyDiseases associated with anti-Bax antibody
 Products by Pathway  Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2020 publications with Bax and Necrosis
 Nervous System Diseases Antibodies  >1868 publications with Bax and Nervous System Diseases
 Heart Diseases Antibodies  >1852 publications with Bax and Heart Diseases
 Ischemia Antibodies  >1546 publications with Bax and Ischemia
 Brain Diseases Antibodies  >1395 publications with Bax and Brain Diseases
 Inflammation Antibodies  >1032 publications with Bax and Inflammation
 Liver Diseases Antibodies  >970 publications with Bax and Liver Diseases
 Breast Neoplasms Antibodies  >962 publications with Bax and Breast Neoplasms
 Intestinal Neoplasms Antibodies  >839 publications with Bax and Intestinal Neoplasms
 Neoplasms, Experimental Antibodies  >770 publications with Bax and Neoplasms, Experimental
Organs/Tissues associated with anti-Bax antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3174 publications with Bax and Blood
 Brain Antibodies  >2456 publications with Bax and Brain
 Liver Antibodies  >1749 publications with Bax and Liver
 Lung Antibodies  >1338 publications with Bax and Lung
 Bone Antibodies  >791 publications with Bax and Bone
 Nerve Antibodies  >737 publications with Bax and Nerve
 Prostate Antibodies  >723 publications with Bax and Prostate
 Skin Antibodies  >518 publications with Bax and Skin
 Stomach Antibodies  >503 publications with Bax and Stomach
 Eye Antibodies  >402 publications with Bax and Eye
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