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anti-BCL10 antibody :: Rabbit Bcl10 (NT) Antibody

Scan QR to view Datasheet Catalog #    MBS194035 anti-BCL10 antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcl10 (NT), Antibody

 Also Known As   

Anti-Bcl10 (NT) Antibody

 Product Synonym Names    Anti-Bcl10 (NT); Bcl10 (NT)
 Product Gene Name   

anti-BCL10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (85731459..85742587, complement). Location: 1p22
 OMIM    603517
 3D Structure    ModBase 3D Structure for O95999
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 Host    Rabbit
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 Specificity    Anti-Bcl10 (NT) [Rabbit antibody to peptide corresponding to aa 5-19 of human Bcl10.]
This antibody recognizes human Bcl10 (31kD).
 Form/Format    100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to aa 5-19 of human Bcl10.
 Stabilizer    None
 Preservatives    0.02% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-BCL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BCL10 antibody

   Apoptosis is regulated by death domain (DD)- and/or caspase recruitment domain (CARD)-containing molecules and a caspase family of proteases. CARD-containing cell death regulators include ARC, RAIDD, Apaf-1, caspase- 9, and caspase-2. A novel CARD containing protein was recently identified and designated Bcl10, CIPER, mE10, CARMEN, and CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF- kappa B activation. Bcl10 interacts with caspase-9, enhances procaspase- 9 processing, and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphoma and in B and T cell lymphomas indicating that it may be commonly involved in the pathogenesis of human tumors. Bcl10 is expressed in many human and murine tissues and cell lines.
 Product Categories/Family for anti-BCL10 antibody    Apoptosis Antibodies
 Applications Tested/Suitable for anti-BCL10 antibody   

Immunoblot

 Application Notes for anti-BCL10 antibody    Immunoblotting: use at 1:500 dilution.
Positive control: Whole cell lysate of Raji cells.
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NCBI/Uniprot data below describe general gene information for BCL10. It may not necessarily be applicable to this product.
 NCBI GI #    4502379
 NCBI GeneID    8915
 NCBI Accession #    NP_003912.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003921.4 [Other Products]
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 UniProt Primary Accession #    O95999 [Other Products]
 UniProt Related Accession #    O95999; Q5VUF1 [Other Products]
 Molecular Weight    26,252 Da [Similar Products]
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 NCBI Official Full Name    B-cell lymphoma/leukemia 10
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 10
 NCBI Official Symbol    BCL10 [Similar Products]
 NCBI Official Synonym Symbols   
CLAP; mE10; CIPER; c-E10; CARMEN
[Similar Products]
 NCBI Protein Information    B-cell lymphoma/leukemia 10; hCLAP; bcl-10; cCARMEN; cellular-E10; OTTHUMP00000011647; OTTHUMP00000036080; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
 UniProt Protein Name    B-cell lymphoma/leukemia 10
 UniProt Synonym Protein Names   
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10
 Protein Family    B-cell lymphoma/leukemia
 UniProt Gene Name    BCL10 [Similar Products]
 UniProt Synonym Gene Names    CIPER; CLAP [Similar Products]
 UniProt Entry Name    BCL10_HUMAN
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 NCBI Summary for BCL10    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]
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 UniProt Comments for BCL10    Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Transcription, coactivator/corepressor; Tumor suppressor; Apoptosis

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; protein complex; lysosome; immunological synapse; cytosol; lipid raft; T cell receptor complex; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; nucleus

Molecular Function: protein C-terminus binding; protein kinase B binding; ubiquitin binding; protein self-association; protease binding; transcription coactivator activity; protein kinase binding; transcription factor binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding

Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; B cell apoptosis; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; lymphotoxin A biosynthetic process; regulation of T cell receptor signaling pathway; neural tube closure; toll-like receptor signaling pathway; innate immune response; cellular defense response; positive regulation of mast cell cytokine production; immunoglobulin mediated immune response; positive regulation of T cell activation; positive regulation of phosphorylation

Disease: Follicular Lymphoma, Susceptibility To, 1; Mesothelioma, Malignant; Testicular Germ Cell Tumor; Gastric Lymphoma, Primary; Immunodeficiency 37
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 Research Articles on BCL10    1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL10 antibodyPathways associated with anti-BCL10 antibody
 Reference Product  PubMed Publications
 MALT1 antibody  >181 publications with BCL10 and MALT1
 CARD11 antibody  >72 publications with BCL10 and CARD11
 CARD9 antibody  >24 publications with BCL10 and CARD9
 CHUK antibody  >18 publications with BCL10 and CHUK
 CARD10 antibody  >16 publications with BCL10 and CARD10
 TRAF2 antibody  >12 publications with BCL10 and TRAF2
 TLR4 antibody  >10 publications with BCL10 and TLR4
 CASP9 antibody  >8 publications with BCL10 and CASP9
 IKBKG antibody  >5 publications with BCL10 and IKBKG
 CARD14 antibody  >5 publications with BCL10 and CARD14
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-BCL10 antibodyOrgans/Tissues associated with anti-BCL10 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >209 publications with BCL10 and Neoplasms
 Lymphoma Antibodies  >202 publications with BCL10 and Lymphoma
 Lymphoma, B-Cell Antibodies  >173 publications with BCL10 and Lymphoma, B-Cell
 Death Antibodies  >28 publications with BCL10 and Death
 Necrosis Antibodies  >27 publications with BCL10 and Necrosis
 Stomach Neoplasms Antibodies  >27 publications with BCL10 and Stomach Neoplasms
 Leukemia Antibodies  >26 publications with BCL10 and Leukemia
 Cell Transformation, Neoplastic Antibodies  >10 publications with BCL10 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >10 publications with BCL10 and Adenocarcinoma
 Skin Diseases Antibodies  >10 publications with BCL10 and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >103 publications with BCL10 and Blood
 Stomach Antibodies  >38 publications with BCL10 and Stomach
 Lung Antibodies  >15 publications with BCL10 and Lung
 Intestine Antibodies  >13 publications with BCL10 and Intestine
 Lymph Node Antibodies  >13 publications with BCL10 and Lymph Node
 Nerve Antibodies  >11 publications with BCL10 and Nerve
 Skin Antibodies  >9 publications with BCL10 and Skin
 Bone Antibodies  >9 publications with BCL10 and Bone
 Liver Antibodies  >8 publications with BCL10 and Liver
 Bone Marrow Antibodies  >8 publications with BCL10 and Bone Marrow
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