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anti-BLM antibody :: Rabbit anti-Human Bloom Syndrome (Phospho-Thr99) Antibody

Scan QR to view Datasheet Catalog #    MBS003797 anti-BLM antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bloom Syndrome (Phospho-Thr99) (BLM), Antibody

 Also Known As   

Rabbit Bloom Syndrome (Phospho-Thr99) Antibody

 Product Gene Name   

anti-BLM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (91260579..91358686). Location: 15q26.1
 OMIM    210900
 3D Structure    ModBase 3D Structure for P54132
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-BLM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BLM antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for BLM. It may not necessarily be applicable to this product.
 NCBI GI #    4557365
 NCBI GeneID    641
 NCBI Accession #    NP_000048.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000057.2 [Other Products]
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 UniProt Primary Accession #    P54132 [Other Products]
 UniProt Secondary Accession #    Q52M96 [Other Products]
 UniProt Related Accession #    P54132 [Other Products]
 Molecular Weight    159,000 Da [Similar Products]
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 NCBI Official Full Name    Bloom syndrome protein
 NCBI Official Synonym Full Names    Bloom syndrome, RecQ helicase-like
 NCBI Official Symbol    BLM [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    Bloom syndrome protein; recQ protein-like 3; DNA helicase, RecQ-like type 2
 UniProt Protein Name    Bloom syndrome protein
 UniProt Synonym Protein Names   
DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3
 Protein Family    Bloom syndrome protein
 UniProt Gene Name    BLM [Similar Products]
 UniProt Synonym Gene Names    RECQ2; RECQL3; RecQ2 [Similar Products]
 UniProt Entry Name    BLM_HUMAN
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 NCBI Summary for BLM    The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BLM    BLM: a magnesium-dependent ATP-dependent DNA-helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. A member of the RecQ helicase family that is required for genome stability. Participates in DNA replication, recombination and repair. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex which is a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2.

Protein type: DNA repair, damage; DNA replication; Helicase; EC

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: male germ cell nucleus; nuclear chromosome; lateral element; chromosome, telomeric region; PML body; nuclear matrix; pronucleus; cytoplasm; nucleolus; replication fork; nucleus

Molecular Function: four-way junction helicase activity; G-quadruplex DNA binding; ATP-dependent DNA helicase activity; protein binding; ATP-dependent 3'-5' DNA helicase activity; p53 binding; ATPase activity; ATP-dependent helicase activity; bubble DNA binding; helicase activity; single-stranded DNA binding; ATP binding

Biological Process: negative regulation of DNA recombination; regulation of binding; positive regulation of transcription, DNA-dependent; negative regulation of mitotic recombination; DNA double-strand break processing; alpha-beta T cell differentiation; negative regulation of cell division; DNA repair; double-strand break repair via homologous recombination; DNA duplex unwinding; protein oligomerization; DNA recombination; replication fork processing; mitotic cell cycle G2/M transition DNA damage checkpoint; DNA strand renaturation; positive regulation of alpha-beta T cell proliferation; replication fork protection; regulation of cyclin-dependent protein kinase activity; response to DNA damage stimulus; telomere maintenance; response to X-ray

Disease: Bloom Syndrome
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 Research Articles on BLM    1. Eighteen polymorphisms in four DNA repair genes were genotyped in 789 age related cataract patients and 531 normal controls from the Jiangsu Eye Study.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BLM antibodyPathways associated with anti-BLM antibody
 Reference Product  PubMed Publications
 WRN antibody  >201 publications with BLM and WRN
 RAD51 antibody  >73 publications with BLM and RAD51
 CASP3 antibody  >15 publications with BLM and CASP3
 MLH1 antibody  >15 publications with BLM and MLH1
 RPA1 antibody  >13 publications with BLM and RPA1
 FANCD2 antibody  >12 publications with BLM and FANCD2
 FEN1 antibody  >10 publications with BLM and FEN1
 TP53 antibody  >10 publications with BLM and TP53
 TP53BP1 antibody  >9 publications with BLM and TP53BP1
 MX1 antibody  >2 publications with BLM and MX1
 Products by Pathway  Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Bloom's Syndrome Complex Pathway antibodies  Bloom's Syndrome Complex Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Cancer Pathway antibodies  Integrated Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
Diseases associated with anti-BLM antibodyOrgans/Tissues associated with anti-BLM antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >587 publications with BLM and Neoplasms
 Bloom Syndrome Antibodies  >422 publications with BLM and Bloom Syndrome
 Drug Toxicity Antibodies  >381 publications with BLM and Drug Toxicity
 Fibrosis Antibodies  >321 publications with BLM and Fibrosis
 Neoplasms, Experimental Antibodies  >139 publications with BLM and Neoplasms, Experimental
 Chromosome Aberrations Antibodies  >126 publications with BLM and Chromosome Aberrations
 Carcinoma, Squamous Cell Antibodies  >115 publications with BLM and Carcinoma, Squamous Cell
 Inflammation Antibodies  >95 publications with BLM and Inflammation
 Necrosis Antibodies  >79 publications with BLM and Necrosis
 Lung Neoplasms Antibodies  >59 publications with BLM and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >404 publications with BLM and Lung
 Blood Antibodies  >339 publications with BLM and Blood
 Kidney Antibodies  >166 publications with BLM and Kidney
 Liver Antibodies  >99 publications with BLM and Liver
 Intestine Antibodies  >92 publications with BLM and Intestine
 Muscle Antibodies  >83 publications with BLM and Muscle
 Skin Antibodies  >76 publications with BLM and Skin
 Lymph Node Antibodies  >58 publications with BLM and Lymph Node
 Brain Antibodies  >53 publications with BLM and Brain
 Spleen Antibodies  >37 publications with BLM and Spleen
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