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anti-C/EBP-beta antibody :: Rabbit C/EBP-beta (Ab-235/188) Antibody

Scan QR to view Datasheet Catalog #    MBS001623 anti-C/EBP-beta antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C/EBP-beta (Ab-235/188), Antibody

 Also Known As   

Rabbit C/EBP-beta (Ab-235/188) Antibody

 Product Synonym Names    C/EBP-b (Ab-235/188)
 Product Gene Name   

anti-C/EBP-beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (48807120..48809227). Location: 20q13.1
 OMIM    189965
 3D Structure    ModBase 3D Structure for P17676
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-C/EBP-beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-C/EBP-beta antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for C/EBP-beta. It may not necessarily be applicable to this product.
 NCBI GI #    28872796
 NCBI GeneID    1051
 NCBI Accession #    NP_005185.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005194.3 [Other Products]
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 UniProt Primary Accession #    P17676 [Other Products]
 UniProt Secondary Accession #    Q96IH2; Q9H4Z5; A8K671 [Other Products]
 UniProt Related Accession #    P17676 [Other Products]
 Molecular Weight    36,106 Da
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 NCBI Official Full Name    CCAAT/enhancer-binding protein beta
 NCBI Official Synonym Full Names    CCAAT/enhancer binding protein (C/EBP), beta
 NCBI Official Symbol    CEBPB [Similar Products]
 NCBI Official Synonym Symbols   
LAP; CRP2; TCF5; IL6DBP; NF-IL6; C/EBP-beta
[Similar Products]
 NCBI Protein Information    CCAAT/enhancer-binding protein beta; TCF-5; nuclear factor NF-IL6; transcription factor 5; nuclear factor of interleukin 6; interleukin 6-dependent DNA-binding protein; liver-enriched transcriptional activator protein
 UniProt Protein Name    CCAAT/enhancer-binding protein beta
 UniProt Synonym Protein Names   
Liver activator protein; Nuclear factor NF-IL6; Transcription factor 5
 UniProt Gene Name    CEBPB [Similar Products]
 UniProt Synonym Gene Names    LAP; TCF5; C/EBP beta; TCF-5 [Similar Products]
 UniProt Entry Name    CEBPB_HUMAN
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 NCBI Summary for C/EBP-beta    The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C/EBP-beta    C/EBP-beta: a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2.

Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: nucleoplasm; nuclear matrix; nuclear chromatin; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; chromatin binding; transcription factor activity; transcription factor binding; glucocorticoid receptor binding

Biological Process: transcription from RNA polymerase II promoter; embryonic placenta development; regulation of interleukin-6 biosynthetic process; mammary gland epithelial cell proliferation; response to lipopolysaccharide; neuron differentiation; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; brown fat cell differentiation; acute-phase response; positive regulation of fat cell differentiation; immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; inflammatory response; negative regulation of transcription, DNA-dependent
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 Research Articles on C/EBP-beta    1. C/EBPbeta regulates interleukin (IL)-1beta astrocytic inflammatory genes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C/EBP-beta antibodyPathways associated with anti-C/EBP-beta antibody
 Reference Product  PubMed Publications
 CEBPA antibody  >38 publications with C/EBP-beta and CEBPA
 CEBPD antibody  >20 publications with C/EBP-beta and CEBPD
 DDIT3 antibody  >7 publications with C/EBP-beta and DDIT3
 MYC antibody  >6 publications with C/EBP-beta and MYC
 SP1 antibody  >5 publications with C/EBP-beta and SP1
 NFKB1 antibody  >5 publications with C/EBP-beta and NFKB1
 CREB1 antibody  >4 publications with C/EBP-beta and CREB1
 RUNX2 antibody  >4 publications with C/EBP-beta and RUNX2
 EGR1 antibody  >4 publications with C/EBP-beta and EGR1
 CEBPG antibody  >3 publications with C/EBP-beta and CEBPG
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
Diseases associated with anti-C/EBP-beta antibodyOrgans/Tissues associated with anti-C/EBP-beta antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >39 publications with C/EBP-beta and Neoplasms
 Inflammation Antibodies  >18 publications with C/EBP-beta and Inflammation
 Necrosis Antibodies  >8 publications with C/EBP-beta and Necrosis
 Brain Diseases Antibodies  >7 publications with C/EBP-beta and Brain Diseases
 Nervous System Diseases Antibodies  >7 publications with C/EBP-beta and Nervous System Diseases
 Lung Diseases Antibodies  >6 publications with C/EBP-beta and Lung Diseases
 Fatty Liver Antibodies  >5 publications with C/EBP-beta and Fatty Liver
 Cardiovascular Diseases Antibodies  >4 publications with C/EBP-beta and Cardiovascular Diseases
 Liver Diseases Antibodies  >4 publications with C/EBP-beta and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with C/EBP-beta and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with C/EBP-beta and Blood
 Bone Antibodies  >22 publications with C/EBP-beta and Bone
 Liver Antibodies  >21 publications with C/EBP-beta and Liver
 Bone Marrow Antibodies  >16 publications with C/EBP-beta and Bone Marrow
 Muscle Antibodies  >11 publications with C/EBP-beta and Muscle
 Lung Antibodies  >11 publications with C/EBP-beta and Lung
 Brain Antibodies  >10 publications with C/EBP-beta and Brain
 Embryonic Tissue Antibodies  >5 publications with C/EBP-beta and Embryonic Tissue
 Heart Antibodies  >5 publications with C/EBP-beta and Heart
 Uterus Antibodies  >5 publications with C/EBP-beta and Uterus
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