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anti-C-RAF antibody :: Rabbit C-RAF (Phospho-Tyr341) Antibody

Scan QR to view Datasheet Catalog #    MBS003491 anti-C-RAF antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-RAF (Phospho-Tyr341), Antibody

 Also Known As   

Rabbit C-RAF (Phospho-Tyr341) Antibody

 Product Gene Name   

anti-C-RAF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (12625100..12705700, complement). Location: 3p25
 OMIM    164760
 3D Structure    ModBase 3D Structure for P04049
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-C-RAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-C-RAF antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for C-RAF. It may not necessarily be applicable to this product.
 NCBI GI #    4506401
 NCBI GeneID    5894
 NCBI Accession #    NP_002871.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002880.3 [Other Products]
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 UniProt Primary Accession #    P04049 [Other Products]
 UniProt Secondary Accession #    Q15278; Q9UC20; B0LPH8; B2R5N3 [Other Products]
 UniProt Related Accession #    P04049 [Other Products]
 Molecular Weight    73,052 Da
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 NCBI Official Full Name    RAF proto-oncogene serine/threonine-protein kinase
 NCBI Official Synonym Full Names    v-raf-1 murine leukemia viral oncogene homolog 1
 NCBI Official Symbol    RAF1 [Similar Products]
 NCBI Official Synonym Symbols   
NS5; CRAF; Raf-1; c-Raf
[Similar Products]
 NCBI Protein Information    RAF proto-oncogene serine/threonine-protein kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase
 UniProt Protein Name    RAF proto-oncogene serine/threonine-protein kinase
 UniProt Synonym Protein Names   
Proto-oncogene c-RAF; cRaf; Raf-1
 UniProt Gene Name    RAF1 [Similar Products]
 UniProt Synonym Gene Names    RAF; cRaf [Similar Products]
 UniProt Entry Name    RAF1_HUMAN
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 NCBI Summary for C-RAF    This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C-RAF    RAF1: a proto-oncogenic TKL kinase of the RAF family. Functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate and activate MEK1/2, which in turn phosphorylate and activate ERK1/2. Acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MEK1/2) and the extracellular signal-regulated kinases (ERK1/2). RAF1, subsequent to phosphorylation by PAK1, phosphorylates BAD (Bcl2-antagonist of cell death) at S75. Phosphorylates adenylyl cyclases ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2 (cardiac muscle troponin T). Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (ASK1 and MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Oncoprotein; Protein kinase, TKL; EC 2.7.11.1; TKL group; RAF family

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: Golgi apparatus; mitochondrial outer membrane; cytoplasm; plasma membrane; pseudopodium; nucleus; cytosol

Molecular Function: small GTPase binding; identical protein binding; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; protein heterodimerization activity; mitogen-activated protein kinase kinase binding; metal ion binding; ATP binding; protein kinase activity

Biological Process: axon guidance; nerve growth factor receptor signaling pathway; activation of MAPKK activity; wound healing; somatic stem cell maintenance; apoptosis; heart development; intermediate filament cytoskeleton organization and biogenesis; negative regulation of caspase activity; signal transduction; protein amino acid phosphorylation; regulation of apoptosis; negative regulation of cell proliferation; synaptic transmission; small GTPase mediated signal transduction; regulation of cell differentiation; transmembrane transport; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; adenylate cyclase activation; MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; cell proliferation; Ras protein signal transduction; insulin receptor signaling pathway; response to hypoxia; regulation of Rho protein signal transduction; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; negative regulation of protein complex assembly; negative regulation of apoptosis

Disease: Cardiomyopathy, Dilated, 1nn; Noonan Syndrome 5; Leopard Syndrome 2
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 Research Articles on C-RAF    1. these findings establish RanBPM as a novel inhibitor of the ERK pathway through an interaction with the c-Raf complex and a regulation of c-Raf stability
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C-RAF antibodyPathways associated with anti-C-RAF antibody
 Reference Product  PubMed Publications
 KRAS antibody  >67 publications with C-RAF and KRAS
 MAPK1 antibody  >54 publications with C-RAF and MAPK1
 BRAF antibody  >45 publications with C-RAF and BRAF
 MAPK3 antibody  >43 publications with C-RAF and MAPK3
 MAP2K1 antibody  >35 publications with C-RAF and MAP2K1
 SRC antibody  >30 publications with C-RAF and SRC
 MYC antibody  >28 publications with C-RAF and MYC
 NRAS antibody  >24 publications with C-RAF and NRAS
 HRAS antibody  >24 publications with C-RAF and HRAS
 SHOC2 antibody  >15 publications with C-RAF and SHOC2
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-C-RAF antibodyOrgans/Tissues associated with anti-C-RAF antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >140 publications with C-RAF and Neoplasms
 Cardiovascular Diseases Antibodies  >74 publications with C-RAF and Cardiovascular Diseases
 Noonan Syndrome Antibodies  >59 publications with C-RAF and Noonan Syndrome
 Heart Diseases Antibodies  >56 publications with C-RAF and Heart Diseases
 Nervous System Diseases Antibodies  >29 publications with C-RAF and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >22 publications with C-RAF and Cell Transformation, Neoplastic
 Cardiomyopathy, Hypertrophic Antibodies  >20 publications with C-RAF and Cardiomyopathy, Hypertrophic
 Breast Neoplasms Antibodies  >20 publications with C-RAF and Breast Neoplasms
 Lung Neoplasms Antibodies  >20 publications with C-RAF and Lung Neoplasms
 LEOPARD Syndrome Antibodies  >19 publications with C-RAF and LEOPARD Syndrome
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >47 publications with C-RAF and Heart
 Blood Antibodies  >44 publications with C-RAF and Blood
 Lung Antibodies  >37 publications with C-RAF and Lung
 Muscle Antibodies  >25 publications with C-RAF and Muscle
 Liver Antibodies  >21 publications with C-RAF and Liver
 Vascular Antibodies  >19 publications with C-RAF and Vascular
 Brain Antibodies  >19 publications with C-RAF and Brain
 Skin Antibodies  >18 publications with C-RAF and Skin
 Kidney Antibodies  >17 publications with C-RAF and Kidney
 Nerve Antibodies  >10 publications with C-RAF and Nerve
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