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anti-C1S antibody :: Rabbit anti-Human C1S Antibody

Scan QR to view Datasheet Catalog #    MBS851785
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C1S, Antibody

★Popular Item★
 Also Known As   

C1S Antibody

 Product Synonym Names    28S ribosomal protein S7; mitochondrial; S7mt; MRP-S7; bMRP27a; bMRP-27a
 Product Gene Name   

anti-C1S antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613783
 3D Structure    ModBase 3D Structure for P09871
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    C1S antibody detects endogenous levels of total C1S protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Reactivity Note    Human (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human C1S.
 Pathway    Lymphocyte Signaling
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-C1S antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-C1S antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-C1S antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-C1S antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:40000
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 Testing Data of anti-C1S antibody    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using C1S antibody.
anti-C1S antibody Testing Data image
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 Testing Data #2 of anti-C1S antibody    Western blot analysis of extracts from Jurkat cells and COLO cells, using C1S antibody.
anti-C1S antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for C1S. It may not necessarily be applicable to this product.
 NCBI GI #    4502495
 NCBI GeneID    716
 NCBI Accession #    NP_001725.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001734.3 [Other Products]
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 UniProt Primary Accession #    P09871 [Other Products]
 UniProt Secondary Accession #    Q9UCU7; Q9UCU8; Q9UCU9; Q9UCV0; Q9UCV1; Q9UCV2; Q9UCV3; Q9UCV4; Q9UCV5; Q9UM14; D3DUT4 [Other Products]
 UniProt Related Accession #    P09871 [Other Products]
 Molecular Weight    76,684 Da
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 NCBI Official Full Name    complement C1s subcomponent
 NCBI Official Synonym Full Names    complement component 1, s subcomponent
 NCBI Official Symbol    C1S [Similar Products]
 NCBI Protein Information    complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s
 UniProt Protein Name    Complement C1s subcomponent
 UniProt Synonym Protein Names   
C1 esterase; Complement component 1 subcomponent sCleaved into the following 2 chains:Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain
 UniProt Gene Name    C1S [Similar Products]
 UniProt Entry Name    C1S_HUMAN
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 NCBI Summary for C1S    This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
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 UniProt Comments for C1S    C1S: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Defects in C1S are the cause of complement component C1s deficiency (C1SD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Belongs to the peptidase S1 family.

Protein type: Protease; EC

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular region

Molecular Function: identical protein binding; protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: innate immune response; proteolysis; complement activation, classical pathway; complement activation

Disease: Complement Component C1s Deficiency
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Product References and Citations for anti-C1S antibody

   McKinnon C.M., Eur. J. Biochem. 169:547-553(1987).
Tosi M., Biochemistry 26:8516-8524(1987).
Kusumoto H., Proc. Natl. Acad. Sci. U.S.A. 85:7307-7311(1988).
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 Research Articles on C1S    1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-C1S antibodyDiseases associated with anti-C1S antibody
 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >125 publications with C1S and Cardiovascular Diseases
 Autoimmune Diseases Antibodies  >87 publications with C1S and Autoimmune Diseases
 Inflammation Antibodies  >67 publications with C1S and Inflammation
 Edema Antibodies  >43 publications with C1S and Edema
 Kidney Diseases Antibodies  >27 publications with C1S and Kidney Diseases
 Necrosis Antibodies  >21 publications with C1S and Necrosis
 Liver Diseases Antibodies  >20 publications with C1S and Liver Diseases
 Brain Diseases Antibodies  >18 publications with C1S and Brain Diseases
 Disease Models, Animal Antibodies  >17 publications with C1S and Disease Models, Animal
 Weight Loss Antibodies  >15 publications with C1S and Weight Loss
Organs/Tissues associated with anti-C1S antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >295 publications with C1S and Blood
 Bone Antibodies  >68 publications with C1S and Bone
 Vascular Antibodies  >57 publications with C1S and Vascular
 Liver Antibodies  >53 publications with C1S and Liver
 Skin Antibodies  >33 publications with C1S and Skin
 Kidney Antibodies  >31 publications with C1S and Kidney
 Brain Antibodies  >29 publications with C1S and Brain
 Muscle Antibodies  >23 publications with C1S and Muscle
 Embryonic Tissue Antibodies  >20 publications with C1S and Embryonic Tissue
 Lung Antibodies  >16 publications with C1S and Lung
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