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anti-C5 antibody :: C5 Antibody

Scan QR to view Datasheet Catalog #    MBS8517096
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C5, Antibody

★Popular Item★
 Also Known As   

C5 Antibody

 Product Gene Name   

anti-C5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120900
 3D Structure    ModBase 3D Structure for P01031
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 Other Notes    Small volumes of anti-C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Western Blot (WB) of anti-C5 antibody    Western blot analysis C5 using NIH-3T3 whole cell lysates
anti-C5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
 NCBI GI #    953514538
 NCBI GeneID    727
 NCBI Accession #    NP_001304092.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001317163.1 [Other Products]
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 UniProt Primary Accession #    P01031 [Other Products]
 UniProt Secondary Accession #    Q14CJ0; Q27I61 [Other Products]
 UniProt Related Accession #    P01031 [Other Products]
 Molecular Weight    188,305 Da
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 NCBI Official Full Name    complement C5 isoform 2
 NCBI Official Synonym Full Names    complement C5
 NCBI Official Symbol    C5 [Similar Products]
 NCBI Official Synonym Symbols   
C5D; C5a; C5b; ECLZB; CPAMD4
[Similar Products]
 NCBI Protein Information    complement C5
 UniProt Protein Name    Complement C5
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 Protein Family    C5a peptidase
 UniProt Gene Name    C5 [Similar Products]
 UniProt Synonym Gene Names    CPAMD4 [Similar Products]
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 NCBI Summary for C5    This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
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 UniProt Comments for C5    Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
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 Research Articles on C5    1. Mean cerebrospinal fluid C5 levels increased in patients with depression and schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C5 antibodyPathways associated with anti-C5 antibody
 Reference Product  PubMed Publications
 C5AR1 antibody  >23 publications with C5 and C5AR1
 C8A antibody  >6 publications with C5 and C8A
 GPR77 antibody  >6 publications with C5 and GPR77
 C8B antibody  >4 publications with C5 and C8B
 C3AR1 antibody  >2 publications with C5 and C3AR1
 CXCR7 antibody  >1 publications with C5 and CXCR7
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-C5 antibodyOrgans/Tissues associated with anti-C5 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2403 publications with C5 and Nervous System Diseases
 Neurologic Manifestations Antibodies  >1014 publications with C5 and Neurologic Manifestations
 Inflammation Antibodies  >762 publications with C5 and Inflammation
 Cardiovascular Diseases Antibodies  >698 publications with C5 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >674 publications with C5 and Vascular Diseases
 Kidney Diseases Antibodies  >476 publications with C5 and Kidney Diseases
 Anemia Antibodies  >286 publications with C5 and Anemia
 Immunologic Deficiency Syndromes Antibodies  >264 publications with C5 and Immunologic Deficiency Syndromes
 Necrosis Antibodies  >233 publications with C5 and Necrosis
 Heart Diseases Antibodies  >178 publications with C5 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2309 publications with C5 and Bone
 Muscle Antibodies  >1295 publications with C5 and Muscle
 Brain Antibodies  >791 publications with C5 and Brain
 Kidney Antibodies  >519 publications with C5 and Kidney
 Lung Antibodies  >486 publications with C5 and Lung
 Liver Antibodies  >468 publications with C5 and Liver
 Spleen Antibodies  >172 publications with C5 and Spleen
 Bone Marrow Antibodies  >136 publications with C5 and Bone Marrow
 Intestine Antibodies  >124 publications with C5 and Intestine
 Eye Antibodies  >119 publications with C5 and Eye
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