BAA32250.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CAD
NCBI Official Synonym Full Names
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
NCBI Protein Information
DNA fragmentation factor subunit beta; OTTHUMP00000003633; OTTHUMP00000003634; OTTHUMP00000003649; OTTHUMP00000003673; caspase-activated DNase; caspase-activated nuclease; caspase-activated deoxyribonuclease; DNA fragmentation factor 40 kDa subunit
UniProt Protein Name
DNA fragmentation factor subunit beta
UniProt Synonym Protein Names
Caspase-activated deoxyribonuclease; CAD; Caspase-activated DNase; Caspase-activated nuclease; CPAN; DNA fragmentation factor 40 kDa subunit
UniProt Synonym Gene Names
UniProt Entry Name
DFFB_HUMAN
NCBI Summary for DFFB
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq]
UniProt Comments for DFFB
DFFB: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; EC 3.-.-.-; Deoxyribonuclease
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: nucleoplasm; nuclear chromatin; nucleolus; nucleus; cytosol
Molecular Function: enzyme binding; deoxyribonuclease activity
Biological Process: apoptosis; DNA fragmentation during apoptosis; apoptotic chromosome condensation; cell structure disassembly during apoptosis
Research Articles on DFFB
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Products associated with anti-DFFB antibody
Pathways associated with anti-DFFB antibody
Diseases associated with anti-DFFB antibody
Organs/Tissues associated with anti-DFFB antibody
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