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anti-CAPN10 antibody :: Rabbit anti-Human CAPN10 Antibody

Scan QR to view Datasheet Catalog #    MBS858000
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAPN10, Antibody

 Also Known As   

CAPN10 Antibody

 Product Synonym Names    calcium-activated neutral protease; Calcium-activated neutral proteinase 10; calpain 10; Calpain-10; CAN10; CANP 10; CAPN10; KIAA1845; NIDDM1
 Product Gene Name   

anti-CAPN10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605286
 3D Structure    ModBase 3D Structure for Q9HC96
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    CAPN10 antibody detects endogenous levels of total CAPN10 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from N-terminal of human CAPN10.
 Pathway    Intermediates
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-CAPN10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CAPN10 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CAPN10 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CAPN10 antibody    WB: 1:500~1:1000, ELISA: 1:40000
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 Testing Data of anti-CAPN10 antibody    anti-CAPN10 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CAPN10. It may not necessarily be applicable to this product.
 NCBI GI #    13186302
 NCBI GeneID    11132
 NCBI Accession #    NP_075571.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_023083.3 [Other Products]
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 UniProt Primary Accession #    Q9HC96 [Other Products]
 UniProt Secondary Accession #    Q4ZFV1; Q8NCD4; Q96IG4; Q96JI2; Q9HC89; Q9HC90; Q9HC91; Q9HC92; Q9HC93; Q9HC94; A8MVS7 [Other Products]
 UniProt Related Accession #    Q9HC96 [Other Products]
 Molecular Weight    15,275 Da
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 NCBI Official Full Name    calpain-10 isoform a
 NCBI Official Synonym Full Names    calpain 10
 NCBI Official Symbol    CAPN10 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    calpain-10; calpain-like protease CAPN10; calcium-activated neutral proteinase 10
 UniProt Protein Name    Calpain-10
 UniProt Synonym Protein Names   
Calcium-activated neutral proteinase 10; CANP 10
 Protein Family    Calpain
 UniProt Gene Name    CAPN10 [Similar Products]
 UniProt Synonym Gene Names    KIAA1845; CANP 10 [Similar Products]
 UniProt Entry Name    CAN10_HUMAN
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 NCBI Summary for CAPN10    Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
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 UniProt Comments for CAPN10    CAPN10: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Defects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1). It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the peptidase C2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.22.-; Mitochondrial; Apoptosis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: mitochondrion; cell; plasma membrane; cytosol

Molecular Function: SNARE binding; cytoskeletal protein binding; calcium-dependent cysteine-type endopeptidase activity

Biological Process: positive regulation of glucose import; cellular response to insulin stimulus; positive regulation of intracellular transport; actin cytoskeleton reorganization; positive regulation of insulin secretion; proteolysis; cell structure disassembly during apoptosis

Disease: Diabetes Mellitus, Noninsulin-dependent, 1
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Product References and Citations for anti-CAPN10 antibody

   Horikawa Y., Nat. Genet. 26:163-175(2000).
Nagase T., DNA Res. 8:85-95(2001).
Ota T., Nat. Genet. 36:40-45(2004).
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 Research Articles on CAPN10    1. Variations of SNP-43, -63 and Indel-19 of CAPN10 were not associated with an increased risk of developing gestational diabetes mellitus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CAPN10 antibodyDiseases associated with anti-CAPN10 antibody
 Products by Pathway  Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >83 publications with CAPN10 and Diabetes Mellitus, Type 2
 Diabetes Mellitus, Noninsulin-Dependent, 1 Antibodies  >48 publications with CAPN10 and Diabetes Mellitus, Noninsulin-Dependent, 1
 Hypertension Antibodies  >9 publications with CAPN10 and Hypertension
 Skin Diseases Antibodies  >4 publications with CAPN10 and Skin Diseases
 Hyperglycemia Antibodies  >4 publications with CAPN10 and Hyperglycemia
 Congenital Abnormalities Antibodies  >4 publications with CAPN10 and Congenital Abnormalities
 Fatty Liver Antibodies  >3 publications with CAPN10 and Fatty Liver
 Nervous System Diseases Antibodies  >3 publications with CAPN10 and Nervous System Diseases
 Necrosis Antibodies  >2 publications with CAPN10 and Necrosis
 Disease Models, Animal Antibodies  >2 publications with CAPN10 and Disease Models, Animal
Organs/Tissues associated with anti-CAPN10 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with CAPN10 and Blood
 Muscle Antibodies  >11 publications with CAPN10 and Muscle
 Pancreas Antibodies  >8 publications with CAPN10 and Pancreas
 Liver Antibodies  >6 publications with CAPN10 and Liver
 Heart Antibodies  >5 publications with CAPN10 and Heart
 Kidney Antibodies  >5 publications with CAPN10 and Kidney
 Vascular Antibodies  >3 publications with CAPN10 and Vascular
 Adipose Tissue Antibodies  >3 publications with CAPN10 and Adipose Tissue
 Prostate Antibodies  >2 publications with CAPN10 and Prostate
 Brain Antibodies  >2 publications with CAPN10 and Brain
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