NP_001244899.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,270 Da
NCBI Official Full Name
caspase recruitment domain-containing protein 14 isoform 3
NCBI Official Synonym Full Names
caspase recruitment domain family, member 14
NCBI Official Synonym Symbols
PRP; PSS1; BIMP2; CARMA2; PSORS2 [Similar Products]
NCBI Protein Information
caspase recruitment domain-containing protein 14; carma 2; card-maguk protein 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk protein 2
UniProt Protein Name
Caspase recruitment domain-containing protein 14
UniProt Synonym Protein Names
CARD-containing MAGUK protein 2
UniProt Synonym Gene Names
UniProt Entry Name
CAR14_HUMAN
NCBI Summary for CAR14
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
UniProt Comments for CAR14
CARD14: a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: cytoplasm; plasma membrane
Molecular Function: CARD domain binding
Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; activation of NF-kappaB-inducing kinase; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; activation of NF-kappaB transcription factor
Disease: Psoriasis 2; Pityriasis Rubra Pilaris
Research Articles on CAR14
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Products associated with anti-CAR14 antibody
Diseases associated with anti-CAR14 antibody
Organs/Tissues associated with anti-CAR14 antibody
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