NP_001902.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,837 Da
NCBI Official Full Name
cathepsin G preproprotein
NCBI Official Synonym Full Names
cathepsin G
NCBI Official Synonym Symbols
NCBI Protein Information
cathepsin G
UniProt Protein Name
Cathepsin G
UniProt Synonym Gene Names
UniProt Entry Name
CATG_HUMAN
NCBI Summary for CATG
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CATG
CTSG: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. Belongs to the peptidase S1 family.
Protein type: Motility/polarity/chemotaxis; EC 3.4.21.20; Protease
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: extracellular matrix; extracellular space; cell surface; plasma membrane; extracellular region; nucleus; secretory granule
Molecular Function: heparin binding; peptidase activity; serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; positive regulation of immune response; extracellular matrix organization and biogenesis; cellular protein metabolic process; immune response; response to lipopolysaccharide; protein processing; proteolysis; angiotensin maturation; defense response to fungus
Research Articles on CATG
Precautions
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Disclaimer
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Products associated with anti-CATG antibody
Pathways associated with anti-CATG antibody
Diseases associated with anti-CATG antibody
Organs/Tissues associated with anti-CATG antibody
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