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anti-CCKBR antibody :: Rabbit CCKBR Antibody

Scan QR to view Datasheet Catalog #    MBS000433 anti-CCKBR antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCKBR, Antibody

 Also Known As   

Rabbit CCKBR Antibody

 Product Gene Name   

anti-CCKBR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (6280904..6293357). Location: 11p15.4
 OMIM    118445
 3D Structure    ModBase 3D Structure for P32239
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CCKBR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CCKBR antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CCKBR. It may not necessarily be applicable to this product.
 NCBI GI #    28875799
 NCBI GeneID    887
 NCBI Accession #    NP_795344.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_176875.3 [Other Products]
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 UniProt Primary Accession #    P32239 [Other Products]
 UniProt Secondary Accession #    O75824; Q16144; Q92492; Q96LC6; Q9NYK7; Q9UBV1; A8K7P9 [Other Products]
 UniProt Related Accession #    P32239 [Other Products]
 Molecular Weight    48,419 Da
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 NCBI Official Full Name    gastrin/cholecystokinin type B receptor
 NCBI Official Synonym Full Names    cholecystokinin B receptor
 NCBI Official Symbol    CCKBR [Similar Products]
 NCBI Official Synonym Symbols   
GASR; CCK-B; CCK2R
[Similar Products]
 NCBI Protein Information    gastrin/cholecystokinin type B receptor; CCK-BR; CCK2-R; CCK2 receptor; CCK-B receptor; gastrin receptor; cholecystokinin-2 receptor
 UniProt Protein Name    Gastrin/cholecystokinin type B receptor
 UniProt Synonym Protein Names   
Cholecystokinin-2 receptor
 Protein Family    Gastrin/cholecystokinin type B receptor
 UniProt Gene Name    CCKBR [Similar Products]
 UniProt Synonym Gene Names    CCKRB; CCK-B receptor; CCK-BR; CCK2-R [Similar Products]
 UniProt Entry Name    GASR_HUMAN
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 NCBI Summary for CCKBR    This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CCKBR    CCKBR: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: type B gastrin/cholecystokinin receptor binding; protein binding; gastrin receptor activity; 1-phosphatidylinositol-3-kinase regulator activity; cholecystokinin receptor activity; phosphoinositide phospholipase C activity

Biological Process: gastric acid secretion; gland development; metabolic process; regulation of phosphoinositide 3-kinase activity; cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; gut development; sensory perception; positive regulation of cell proliferation; digestion; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
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 Research Articles on CCKBR    1. Gastric mucosal injury with H. pylori infection destroys the pH barrier on the foveolar epithelium and may induce gastrin receptor expression through pH changes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCKBR antibodyPathways associated with anti-CCKBR antibody
 Reference Product  PubMed Publications
 CCK antibody  >670 publications with CCKBR and CCK
 CCKAR antibody  >15 publications with CCKBR and CCKAR
 PTPN11 antibody  >1 publications with CCKBR and PTPN11
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
Diseases associated with anti-CCKBR antibodyOrgans/Tissues associated with anti-CCKBR antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >70 publications with CCKBR and Mental Disorders
 Nervous System Diseases Antibodies  >54 publications with CCKBR and Nervous System Diseases
 Panic Disorder Antibodies  >38 publications with CCKBR and Panic Disorder
 Drug Toxicity Antibodies  >18 publications with CCKBR and Drug Toxicity
 Liver Neoplasms Antibodies  >17 publications with CCKBR and Liver Neoplasms
 Inflammation Antibodies  >15 publications with CCKBR and Inflammation
 Hyperplasia Antibodies  >13 publications with CCKBR and Hyperplasia
 Hyperalgesia Antibodies  >13 publications with CCKBR and Hyperalgesia
 Atrophy Antibodies  >12 publications with CCKBR and Atrophy
 Learning Disorders Antibodies  >9 publications with CCKBR and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >247 publications with CCKBR and Brain
 Stomach Antibodies  >174 publications with CCKBR and Stomach
 Lung Antibodies  >20 publications with CCKBR and Lung
 Embryonic Tissue Antibodies  >7 publications with CCKBR and Embryonic Tissue
 Eye Antibodies  >3 publications with CCKBR and Eye
 Placenta Antibodies  >1 publications with CCKBR and Placenta
 Testis Antibodies  >1 publications with CCKBR and Testis
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