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anti-CD105 antibody :: Mouse anti-Human CD105 Antibody

Scan QR to view Datasheet Catalog #    MBS850485
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD105, Antibody

 Also Known As   

CD105 Antibody

 Product Synonym Names    ENG; END; ORW; HHT1; ORW1; CD105; FLJ41744
 Product Gene Name   

anti-CD105 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    131195
 3D Structure    ModBase 3D Structure for P17813
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 Isotype    IgG1
 Clone Number    3A9
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human CD105 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-CD105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD105 antibody

   This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
 Product Categories/Family for anti-CD105 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CD105 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-CD105 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
FC: 1:200-1:400
ELISA: 1:10000
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 Western Blot (WB) of anti-CD105 antibody    Figure 1: Western blot analysis using CD105 mAb against HEK293 (1) and CD105-hIgGFc transfected HEK293 (2) cell lysate.
anti-CD105 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CD105 antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded kidney cancer tissues (left) and stomach cancer tissues (right) using CD105 mouse mAb with DAB staining.
anti-CD105 antibody Immunohistochemistry (IHC) (IHC) image
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 Testing Data of anti-CD105 antibody    anti-CD105 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD105. It may not necessarily be applicable to this product.
 NCBI GI #    4557555
 NCBI GeneID    2022
 NCBI Accession #    NP_000109.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000118.3 [Other Products]
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 UniProt Primary Accession #    P17813 [Other Products]
 UniProt Secondary Accession #    Q14248; Q14926; Q5T9C0 [Other Products]
 UniProt Related Accession #    P17813 [Other Products]
 Molecular Weight    71kDa
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 NCBI Official Full Name    endoglin isoform 2
 NCBI Official Synonym Full Names    endoglin
 NCBI Official Symbol    ENG [Similar Products]
 NCBI Official Synonym Symbols   
END; HHT1; ORW1
[Similar Products]
 NCBI Protein Information    endoglin
 UniProt Protein Name    Endoglin
 UniProt Synonym Protein Names   
CD_antigen: CD105
 UniProt Gene Name    ENG [Similar Products]
 UniProt Synonym Gene Names    END [Similar Products]
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 NCBI Summary for CD105    This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for CD105    Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
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 Research Articles on CD105    1. high serum level at 26-31 weeks of gestational was a risk factor for a small-for-gestational-age infant at 35-41 weeks
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD105 antibodyPathways associated with anti-CD105 antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >288 publications with CD105 and TGFB1
 ACVRL1 antibody  >135 publications with CD105 and ACVRL1
 BMP2 antibody  >103 publications with CD105 and BMP2
 SMAD4 antibody  >42 publications with CD105 and SMAD4
 HIF1A antibody  >32 publications with CD105 and HIF1A
 TGFBR2 antibody  >4 publications with CD105 and TGFBR2
 TGFBR1 antibody  >3 publications with CD105 and TGFBR1
 GIPC1 antibody  >1 publications with CD105 and GIPC1
 TGFBI antibody  >1 publications with CD105 and TGFBI
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-CD105 antibodyOrgans/Tissues associated with anti-CD105 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5952 publications with CD105 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5124 publications with CD105 and Cardiovascular Diseases
 Neoplasms Antibodies  >3568 publications with CD105 and Neoplasms
 Heart Diseases Antibodies  >2699 publications with CD105 and Heart Diseases
 Breast Neoplasms Antibodies  >689 publications with CD105 and Breast Neoplasms
 Disease Models, Animal Antibodies  >646 publications with CD105 and Disease Models, Animal
 Hypertension Antibodies  >524 publications with CD105 and Hypertension
 Drug Toxicity Antibodies  >511 publications with CD105 and Drug Toxicity
 Inflammation Antibodies  >505 publications with CD105 and Inflammation
 Liver Diseases Antibodies  >411 publications with CD105 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10044 publications with CD105 and Blood
 Heart Antibodies  >7041 publications with CD105 and Heart
 Bone Antibodies  >6758 publications with CD105 and Bone
 Brain Antibodies  >6685 publications with CD105 and Brain
 Muscle Antibodies  >6154 publications with CD105 and Muscle
 Vascular Antibodies  >6009 publications with CD105 and Vascular
 Nerve Antibodies  >2656 publications with CD105 and Nerve
 Skin Antibodies  >2537 publications with CD105 and Skin
 Connective Tissue Antibodies  >2076 publications with CD105 and Connective Tissue
 Eye Antibodies  >1771 publications with CD105 and Eye
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