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ITGAX antibody :: CD11c Antibody

Scan QR to view Datasheet Catalog #    MBS439537 ITGAX antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD11c (ITGAX), Antibody

★Popular Item★
 Also Known As   

CD11c (Dendritic Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95
 Product Gene Name   

ITGAX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151510
 3D Structure    ModBase 3D Structure for P20702
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 Clonality    Monoclonal
 Isotype    IgG2b, kappa
 Host    Mouse
 Species Reactivity    Human.Others not known.
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 Specificity    Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Recombinant human ITGAX protein fragment (aa 637-827)
 Hu-Chromosome Location    16p11.2
 Positive Control    Human dendritic cells. Human lymph nodes and tonsils.
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 Preparation and Storage    Antibody with azide - store at 2 to 8C.
 Other Notes    Small volumes of ITGAX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ITGAX antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for ITGAX antibody    Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1ug/mL)
Immunohistology (Formalin-fixed)(1-2ug/mL for 30 min at RT)
Staining of formalin-fixxed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.

Optimal dilution for specific application should be determined.
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NCBI/Uniprot data below describe general gene information for ITGAX. It may not necessarily be applicable to this product.
 NCBI GI #    34452173
 NCBI GeneID    3687
 NCBI Accession #    NP_000878.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000887.4 [Other Products]
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 UniProt Primary Accession #    P20702 [Other Products]
 UniProt Secondary Accession #    Q8IVA6 [Other Products]
 UniProt Related Accession #    P20702 [Other Products]
 Molecular Weight    145kDa
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 NCBI Official Full Name    integrin alpha-X isoform 2
 NCBI Official Synonym Full Names    integrin subunit alpha X
 NCBI Official Symbol    ITGAX [Similar Products]
 NCBI Official Synonym Symbols   
CD11C; SLEB6
[Similar Products]
 NCBI Protein Information    integrin alpha-X
 UniProt Protein Name    Integrin alpha-X
 UniProt Synonym Protein Names   
CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c
 Protein Family    Integrin
 UniProt Gene Name    ITGAX [Similar Products]
 UniProt Synonym Gene Names    CD11C [Similar Products]
 UniProt Entry Name    ITAX_HUMAN
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 NCBI Summary for ITGAX    This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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 UniProt Comments for ITGAX    ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; organ morphogenesis

Disease: Systemic Lupus Erythematosus
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Product References and Citations for ITGAX antibody

   Nicolaou, F., et al. 2003. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes Ras and JunD. Blood 101: 4033-4041
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 Research Articles on ITGAX    1. Data suggest that blood neutrophils expressing CD11c antigen and EMR2 protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ITGAX antibody Pathways associated with ITGAX antibody
 Reference Product  PubMed Publications
 TNF antibody  >8 publications with ITGAX and TNF
 ITGB2 antibody  >4 publications with ITGAX and ITGB2
 PTPRC antibody  >2 publications with ITGAX and PTPRC
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
Diseases associated with ITGAX antibody Organs/Tissues associated with ITGAX antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >669 publications with ITGAX and Immune System Diseases
 Inflammation Antibodies  >594 publications with ITGAX and Inflammation
 Necrosis Antibodies  >378 publications with ITGAX and Necrosis
 Disease Models, Animal Antibodies  >348 publications with ITGAX and Disease Models, Animal
 Lung Diseases Antibodies  >181 publications with ITGAX and Lung Diseases
 Nervous System Diseases Antibodies  >134 publications with ITGAX and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >119 publications with ITGAX and Cardiovascular Diseases
 Vascular Diseases Antibodies  >108 publications with ITGAX and Vascular Diseases
 Neoplasms, Experimental Antibodies  >107 publications with ITGAX and Neoplasms, Experimental
 Liver Diseases Antibodies  >65 publications with ITGAX and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2329 publications with ITGAX and Blood
 Bone Marrow Antibodies  >580 publications with ITGAX and Bone Marrow
 Spleen Antibodies  >487 publications with ITGAX and Spleen
 Lymph Node Antibodies  >442 publications with ITGAX and Lymph Node
 Lung Antibodies  >316 publications with ITGAX and Lung
 Intestine Antibodies  >150 publications with ITGAX and Intestine
 Brain Antibodies  >110 publications with ITGAX and Brain
 Thymus Antibodies  >79 publications with ITGAX and Thymus
 Kidney Antibodies  >73 publications with ITGAX and Kidney
 Eye Antibodies  >72 publications with ITGAX and Eye
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