NP_003318.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,341 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 4
NCBI Official Synonym Full Names
TNF receptor superfamily member 4
NCBI Official Synonym Symbols
OX40; ACT35; CD134; IMD16; TXGP1L [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
UniProt Synonym Protein Names
ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134
UniProt Synonym Gene Names
NCBI Summary for CD134
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
UniProt Comments for CD134
TNFRSF4: Receptor for TNFSF4/OX40L/GP34.
Protein type: Apoptosis; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: tumor necrosis factor receptor activity
Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; T cell proliferation; tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency 16
Research Articles on CD134
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Pathways associated with anti-CD134 antibody
Diseases associated with anti-CD134 antibody
Organs/Tissues associated with anti-CD134 antibody
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