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anti-CD20 antibody :: Mouse CD20 Antibody

Scan QR to view Datasheet Catalog #    MBS396558 anti-CD20 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD20, Antibody

 Also Known As   

CD20

 Product Gene Name   

anti-CD20 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (60223282..60238225). Location: 11q12
 OMIM    112210
 3D Structure    ModBase 3D Structure for P11836
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 Isotype    IgG1
 Clone Number    DFA-7
 Host    Mouse
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 Purity/Purification    Protein A/G Chromatography
 Form/Format    Provided as solution in phosphate buffered saline with 0.08% sodium azide
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 Immunogen    CD20=Derived from the hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with the LB lymphoblastoid cell line.
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 Preparation and Storage    Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-CD20 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD20 antibody

   Identification of human B cells associated with approximately 10% of peripheral blood lymphocytes.
 Product Categories/Family for anti-CD20 antibody    Single-Color Reagent; Single Color Markers
 Applications Tested/Suitable for anti-CD20 antibody   

Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for CD20. It may not necessarily be applicable to this product.
 NCBI GI #    23110987
 NCBI GeneID    931
 NCBI Accession #    NP_068769.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021950.3 [Other Products]
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 UniProt Primary Accession #    P11836 [Other Products]
 UniProt Secondary Accession #    P08984; Q13963; A6NMS4 [Other Products]
 UniProt Related Accession #    P11836 [Other Products]
 Molecular Weight    33,077 Da
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 NCBI Official Full Name    B-lymphocyte antigen CD20
 NCBI Official Synonym Full Names    membrane-spanning 4-domains, subfamily A, member 1
 NCBI Official Symbol    MS4A1 [Similar Products]
 NCBI Official Synonym Symbols   
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
 UniProt Protein Name    B-lymphocyte antigen CD20
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1
 Protein Family    CD209 antigen
 UniProt Gene Name    MS4A1 [Similar Products]
 UniProt Synonym Gene Names    CD20 [Similar Products]
 UniProt Entry Name    CD20_HUMAN
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 NCBI Summary for CD20    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD20    Function: This protein may be involved in the regulation of B-cell activation and proliferation.

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor Ref.11.

Tissue specificity: Expressed on B-cells.

Post-translational modification: Phosphorylated. Might be functionally regulated by protein kinase(s).

Involvement in disease: Immunodeficiency, common variable, 5 (CVID5) [MIM:613495]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Pharmaceutical use: Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity.

Sequence similarities: Belongs to the MS4A family.

Caution: Epitope 1, mapped in Ref.8, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained.
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 Research Articles on CD20    1. Anti-hCD20 IgE antibodies have in vitro cytotoxic activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD20 antibodyPathways associated with anti-CD20 antibody
 Reference Product  PubMed Publications
 CD19 antibody  >853 publications with CD20 and CD19
 CD22 antibody  >328 publications with CD20 and CD22
 CD79A antibody  >280 publications with CD20 and CD79A
 CD40 antibody  >160 publications with CD20 and CD40
 CD79B antibody  >152 publications with CD20 and CD79B
 POU2AF1 antibody  >6 publications with CD20 and POU2AF1
 LYN antibody  >4 publications with CD20 and LYN
 LCK antibody  >4 publications with CD20 and LCK
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD20 antibodyOrgans/Tissues associated with anti-CD20 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >3462 publications with CD20 and Immune System Diseases
 Neoplasms Antibodies  >3039 publications with CD20 and Neoplasms
 Inflammation Antibodies  >256 publications with CD20 and Inflammation
 Necrosis Antibodies  >222 publications with CD20 and Necrosis
 Carcinoma Antibodies  >178 publications with CD20 and Carcinoma
 Gastrointestinal Diseases Antibodies  >168 publications with CD20 and Gastrointestinal Diseases
 Skin Neoplasms Antibodies  >167 publications with CD20 and Skin Neoplasms
 Hyperplasia Antibodies  >139 publications with CD20 and Hyperplasia
 Drug Toxicity Antibodies  >130 publications with CD20 and Drug Toxicity
 Kidney Diseases Antibodies  >128 publications with CD20 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2932 publications with CD20 and Blood
 Lymph Node Antibodies  >499 publications with CD20 and Lymph Node
 Lymph Antibodies  >479 publications with CD20 and Lymph
 Skin Antibodies  >319 publications with CD20 and Skin
 Kidney Antibodies  >248 publications with CD20 and Kidney
 Spleen Antibodies  >205 publications with CD20 and Spleen
 Vascular Antibodies  >194 publications with CD20 and Vascular
 Lung Antibodies  >171 publications with CD20 and Lung
 Brain Antibodies  >95 publications with CD20 and Brain
 Stomach Antibodies  >84 publications with CD20 and Stomach
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