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CD22 antibody :: CD22 / BL-CAM Antibody

Scan QR to view Datasheet Catalog #    MBS439724 CD22 antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD22 / BL-CAM, Antibody

 Also Known As   

CD22 / BL-CAM Mouse Monoclonal Antibody

 Product Synonym Names    B-lymphocyte cell adhesion molecule (BL-CAM); B-cell receptor CD22; CD22; Lectin 2; Lyb8; Sialic acid-binding Ig-like lectin 2 (Siglec-2); SIGLEC2; T-cell surface antigen Leu-14
 Product Gene Name   

CD22 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107266
 3D Structure    ModBase 3D Structure for P20273
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    FR10B4
 Host    Mouse
 Species Reactivity    Human.
Others not tested
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 Specificity    Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Human Burkitt's lymphoma cells
 Hu-Chromosome Location    19q13.1
 Positive Control    Raji, Daudi, IM9, JY25 and human peripheral blood lymphocytes. Human tonsil and lymphocytes.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of CD22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CD22 antibody   

Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for CD22 antibody    Functional Studies (Order Ab without Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
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NCBI/Uniprot data below describe general gene information for CD22. It may not necessarily be applicable to this product.
 NCBI GI #    297374825
 NCBI GeneID    933
 NCBI Accession #    NP_001172028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001185099.1 [Other Products]
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 UniProt Primary Accession #    P20273 [Other Products]
 UniProt Secondary Accession #    O95699; O95701; O95702; O95703; Q01665; Q32M46; Q92872; Q92873; Q9UQA6; F5GYU4; F5H7U3 [Other Products]
 UniProt Related Accession #    P20273 [Other Products]
 Molecular Weight    130-140kDa
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 NCBI Official Full Name    B-cell receptor CD22 isoform 2
 NCBI Official Synonym Full Names    CD22 molecule
 NCBI Official Symbol    CD22 [Similar Products]
 NCBI Official Synonym Symbols   
SIGLEC2; SIGLEC-2
[Similar Products]
 NCBI Protein Information    B-cell receptor CD22
 UniProt Protein Name    B-cell receptor CD22
 UniProt Synonym Protein Names   
B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22
 Protein Family    B-cell receptor
 UniProt Gene Name    CD22 [Similar Products]
 UniProt Synonym Gene Names    SIGLEC2; BL-CAM; Siglec-2 [Similar Products]
 UniProt Entry Name    CD22_HUMAN
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 UniProt Comments for CD22    CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: plasma membrane

Molecular Function: protein binding
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Product References and Citations for CD22 antibody

   Campana, D., et al., in : Knapp, W., et al. (eds), Leucocyte Typing IV, Oxford Univ. Press, pp 190-192
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 Research Articles on CD22    1. results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD22 antibody Pathways associated with CD22 antibody
 Reference Product  PubMed Publications
 CD19 antibody  >660 publications with CD22 and CD19
 BCR antibody  >155 publications with CD22 and BCR
 CD79B antibody  >80 publications with CD22 and CD79B
 CD79A antibody  >73 publications with CD22 and CD79A
 LYN antibody  >48 publications with CD22 and LYN
 SYK antibody  >33 publications with CD22 and SYK
 GRB2 antibody  >10 publications with CD22 and GRB2
 PTPRC antibody  >4 publications with CD22 and PTPRC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CD22 Mediated BCR Regulation Pathway antibodies  CD22 Mediated BCR Regulation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with CD22 antibody Organs/Tissues associated with CD22 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1008 publications with CD22 and Immune System Diseases
 Chromosome Aberrations Antibodies  >78 publications with CD22 and Chromosome Aberrations
 Inflammation Antibodies  >62 publications with CD22 and Inflammation
 Respiratory Tract Diseases Antibodies  >51 publications with CD22 and Respiratory Tract Diseases
 Necrosis Antibodies  >50 publications with CD22 and Necrosis
 Disease Models, Animal Antibodies  >49 publications with CD22 and Disease Models, Animal
 Lung Diseases Antibodies  >25 publications with CD22 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >24 publications with CD22 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >23 publications with CD22 and Kidney Diseases
 Liver Diseases Antibodies  >20 publications with CD22 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1098 publications with CD22 and Blood
 Bone Marrow Antibodies  >304 publications with CD22 and Bone Marrow
 Spleen Antibodies  >125 publications with CD22 and Spleen
 Lymph Node Antibodies  >115 publications with CD22 and Lymph Node
 Lymph Antibodies  >103 publications with CD22 and Lymph
 Skin Antibodies  >53 publications with CD22 and Skin
 Lung Antibodies  >35 publications with CD22 and Lung
 Kidney Antibodies  >33 publications with CD22 and Kidney
 Tonsil Antibodies  >31 publications with CD22 and Tonsil
 Thymus Antibodies  >30 publications with CD22 and Thymus
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