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TNFRSF8 antibody :: CD30 / TNFRSF8 Antibody

Scan QR to view Datasheet Catalog #    MBS439816
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD30 / TNFRSF8, Antibody

★Popular Item★
 Also Known As   

CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    CD30L receptor, Cytokine receptor CD30, Ki-1 antigen, Lymphocyte activation antigen CD30, Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
 Product Gene Name   

TNFRSF8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153243
 3D Structure    ModBase 3D Structure for P28908
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM609
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Recombinant human TNFRSF8 protein
 Hu-Chromosome Location    1p36.22
 Positive Control    Hodgkin's lymphoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of TNFRSF8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TNFRSF8 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for TNFRSF8 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of TNFRSF8 antibody    Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with CD30 Monoclonal Antibody (SPM609).
TNFRSF8 antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TNFRSF8. It may not necessarily be applicable to this product.
 NCBI GI #    597709795
 NCBI GeneID    943
 NCBI Accession #    NP_001234.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243.4 [Other Products]
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 UniProt Primary Accession #    P28908 [Other Products]
 UniProt Secondary Accession #    Q6P4D9; B1AN79; B9EGD9; D3YTD8 [Other Products]
 UniProt Related Accession #    P28908 [Other Products]
 Molecular Weight    105-120kDa
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 8 isoform 1
 NCBI Official Synonym Full Names    TNF receptor superfamily member 8
 NCBI Official Symbol    TNFRSF8 [Similar Products]
 NCBI Official Synonym Symbols   
CD30; Ki-1; D1S166E
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 8
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 8
 UniProt Synonym Protein Names   
CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF8 [Similar Products]
 UniProt Synonym Gene Names    CD30; D1S166E [Similar Products]
 UniProt Entry Name    TNR8_HUMAN
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 NCBI Summary for TNFRSF8    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFRSF8    TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to lipopolysaccharide; signal transduction
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Product References and Citations for TNFRSF8 antibody

   Smith, C.A., et al. 1993. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 73: 1349-1360.
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 Research Articles on TNFRSF8    1. Most angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma-not otherwise specified express variable levels of CD30.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF8 antibody Pathways associated with TNFRSF8 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >415 publications with TNFRSF8 and CD4
 ALK antibody  >200 publications with TNFRSF8 and ALK
 CD5 antibody  >105 publications with TNFRSF8 and CD5
 TNFSF8 antibody  >97 publications with TNFRSF8 and TNFSF8
 TRAF2 antibody  >36 publications with TNFRSF8 and TRAF2
 TRAF1 antibody  >27 publications with TNFRSF8 and TRAF1
 ICAM1 antibody  >23 publications with TNFRSF8 and ICAM1
 TRAF3 antibody  >13 publications with TNFRSF8 and TRAF3
 TRAF5 antibody  >10 publications with TNFRSF8 and TRAF5
 FUT4 antibody  >6 publications with TNFRSF8 and FUT4
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with TNFRSF8 antibody Organs/Tissues associated with TNFRSF8 antibody
 Disease Name  Pubmed Publications
 Hodgkin Disease Antibodies  >603 publications with TNFRSF8 and Hodgkin Disease
 Necrosis Antibodies  >319 publications with TNFRSF8 and Necrosis
 Inflammation Antibodies  >96 publications with TNFRSF8 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >68 publications with TNFRSF8 and Cell Transformation, Neoplastic
 Fever Antibodies  >65 publications with TNFRSF8 and Fever
 Hyperplasia Antibodies  >59 publications with TNFRSF8 and Hyperplasia
 Neoplasm Metastasis Antibodies  >51 publications with TNFRSF8 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >48 publications with TNFRSF8 and Disease Models, Animal
 Liver Diseases Antibodies  >46 publications with TNFRSF8 and Liver Diseases
 Fibrosis Antibodies  >29 publications with TNFRSF8 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1220 publications with TNFRSF8 and Blood
 Lymph Node Antibodies  >360 publications with TNFRSF8 and Lymph Node
 Lung Antibodies  >79 publications with TNFRSF8 and Lung
 Intestine Antibodies  >29 publications with TNFRSF8 and Intestine
 Embryonic Tissue Antibodies  >24 publications with TNFRSF8 and Embryonic Tissue
 Testis Antibodies  >23 publications with TNFRSF8 and Testis
 Uterus Antibodies  >7 publications with TNFRSF8 and Uterus
 Salivary Gland Antibodies  >2 publications with TNFRSF8 and Salivary Gland
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