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PECAM1 antibody :: CD31 / PECAM-1 Antibody

Scan QR to view Datasheet Catalog #    MBS439598 PECAM1 antibody
Unit / Price
0.5 mL  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD31 / PECAM-1 (PECAM1), Antibody

★Popular Item★
 Also Known As   

CD31 / PECAM-1 (Endothelial Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'
 Product Gene Name   

PECAM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173445
 3D Structure    ModBase 3D Structure for P16284
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    JC/70A
 Host    Mouse
 Species Reactivity    Human, Cynomolgus Monkey, Rabbit.
Does not react with Rat and Pig
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 Specificity    CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
 Form/Format    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
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 Cellular Localization    Cell Surface and Cytoplasmic
 Immunogen    Membrane preparation of a spleen from a patient with hairy cell leukemia
 Hu-Chromosome Location    17q23.3
 Positive Control    Jurkat, CCRF-CEM or K-562 Cells. Tonsil, Angiosarcoma
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 Preparation and Storage    Antibody with azide - store at 4 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of PECAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PECAM1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for PECAM1 antibody    Flow Cytometry (5ul per test per one million cells in 0.1ml or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100 for 30 minutes at RT)
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NCBI/Uniprot data below describe general gene information for PECAM1. It may not necessarily be applicable to this product.
 NCBI GI #    313760624
 NCBI GeneID    5175
 NCBI Accession #    NP_000433.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000442.4 [Other Products]
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 UniProt Primary Accession #    P16284 [Other Products]
 UniProt Secondary Accession #    Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; A8K3S7; D3DU31 [Other Products]
 UniProt Related Accession #    P16284 [Other Products]
 Molecular Weight    ~100kDa (endothelium); ~130kDa (platelets)
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 NCBI Official Full Name    platelet endothelial cell adhesion molecule
 NCBI Official Synonym Full Names    platelet and endothelial cell adhesion molecule 1
 NCBI Official Symbol    PECAM1 [Similar Products]
 NCBI Official Synonym Symbols   
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
[Similar Products]
 NCBI Protein Information    platelet endothelial cell adhesion molecule
 UniProt Protein Name    Platelet endothelial cell adhesion molecule
 UniProt Synonym Protein Names   
EndoCAM; GPIIA'; PECA1; CD_antigen: CD31
 Protein Family    Platelet endothelial cell adhesion molecule
 UniProt Gene Name    PECAM1 [Similar Products]
 UniProt Synonym Gene Names    PECAM-1 [Similar Products]
 UniProt Entry Name    PECA1_HUMAN
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 NCBI Summary for PECAM1    The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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 UniProt Comments for PECAM1    PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; plasma membrane; platelet alpha granule membrane

Molecular Function: protein binding

Biological Process: cell recognition; diapedesis; extracellular matrix organization and biogenesis; leukocyte migration; phagocytosis; platelet degranulation; signal transduction
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Product References and Citations for PECAM1 antibody

   Gratzinger D et. al. Am J Clin Pathol 131:264-278 (2009).
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 Research Articles on PECAM1    1. soluble CD38 (sCD38) in seminal plasma increases the capacitation of sperm via specific interactions between sCD38 and the CD31 on the sperm.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PECAM1 antibody Diseases associated with PECAM1 antibody
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with PECAM1 and Inflammation
 Atherosclerosis Antibodies  >11 publications with PECAM1 and Atherosclerosis
 Necrosis Antibodies  >9 publications with PECAM1 and Necrosis
 Heart Diseases Antibodies  >9 publications with PECAM1 and Heart Diseases
 Myocardial Infarction Antibodies  >7 publications with PECAM1 and Myocardial Infarction
 Autoimmune Diseases Antibodies  >7 publications with PECAM1 and Autoimmune Diseases
 Fibrosis Antibodies  >6 publications with PECAM1 and Fibrosis
 Thrombosis Antibodies  >5 publications with PECAM1 and Thrombosis
 Kidney Diseases Antibodies  >4 publications with PECAM1 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with PECAM1 and Breast Neoplasms
Organs/Tissues associated with PECAM1 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >81 publications with PECAM1 and Vascular
 Blood Antibodies  >77 publications with PECAM1 and Blood
 Embryonic Tissue Antibodies  >22 publications with PECAM1 and Embryonic Tissue
 Muscle Antibodies  >22 publications with PECAM1 and Muscle
 Heart Antibodies  >15 publications with PECAM1 and Heart
 Lung Antibodies  >10 publications with PECAM1 and Lung
 Brain Antibodies  >10 publications with PECAM1 and Brain
 Placenta Antibodies  >9 publications with PECAM1 and Placenta
 Connective Tissue Antibodies  >8 publications with PECAM1 and Connective Tissue
 Adipose Tissue Antibodies  >5 publications with PECAM1 and Adipose Tissue
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