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CD34 antibody

Scan QR to view Datasheet Catalog #    MBS438569
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD34, Antibody

★Popular Item★
 Also Known As   

CD34 (Hematopoietic Stem Cell & Endothelial Marker) Mouse Monoclonal Antibody

 Product Synonym Names    Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin
 Product Gene Name   

CD34 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142230
 3D Structure    ModBase 3D Structure for P28906
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    HPCA1/763
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and KAP'si s sarcoma, but with a lower specificity.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Recombinant full-length human HPCA1 protein
 Hu-Chromosome Location    1q32.2
 Positive Control    KG-1 cells, Tonsil, or Angiosarcoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody is stable for 24 months.,Non-hazardous. No MSDS required.
 Other Notes    Small volumes of CD34 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CD34 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for CD34 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of CD34 antibody    Formalin-fixed, paraffin-embedded human Angiosarcoma stained with CD34 Monoclonal Antibody (HPCA1/763)
CD34 antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of CD34 antibody    Formalin-fixed, paraffin-embedded human Tonsil stained with CD34 Monoclonal Antibody (HPCA1/763)
CD34 antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of CD34 antibody    Formalin-fixed, paraffin-embedded human Placenta stained with CD34 Monoclonal Antibody (HPCA1/763)
CD34 antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD34. It may not necessarily be applicable to this product.
 NCBI GI #    68342038
 NCBI GeneID    947
 NCBI Accession #    NP_001020280.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025109.1 [Other Products]
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 UniProt Primary Accession #    P28906 [Other Products]
 UniProt Secondary Accession #    Q15970; Q15971; Q5JTA3; Q5JTA4; Q9UJB1; A8K664 [Other Products]
 UniProt Related Accession #    P28906 [Other Products]
 Molecular Weight    90-110kDa
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 NCBI Official Full Name    hematopoietic progenitor cell antigen CD34 isoform a
 NCBI Official Synonym Full Names    CD34 molecule
 NCBI Official Symbol    CD34 [Similar Products]
 NCBI Protein Information    hematopoietic progenitor cell antigen CD34
 UniProt Protein Name    Hematopoietic progenitor cell antigen CD34
 UniProt Synonym Protein Names   
CD_antigen: CD34
 Protein Family    Hematopoietic progenitor cell antigen
 UniProt Gene Name    CD34 [Similar Products]
 UniProt Entry Name    CD34_HUMAN
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 NCBI Summary for CD34    The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CD34    CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: apical plasma membrane; basal plasma membrane; cytoplasm; external side of plasma membrane; integral to plasma membrane; intercellular bridge; lysosome; perinuclear region of cytoplasm; plasma membrane

Molecular Function: carbohydrate binding; transcription factor binding

Biological Process: cell motility involved in cell locomotion; cell proliferation; cell-cell adhesion; cell-matrix adhesion; endothelial cell proliferation; glomerular filtration; hemopoiesis; leukocyte migration; negative regulation of blood coagulation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of interleukin-10 production; positive regulation of odontogenesis; regulation of blood pressure; regulation of immune response; signal transduction; tissue homeostasis
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Product References and Citations for CD34 antibody

   Sato T et al. Blood 94:2548-2554 (1999). Felshow DM et al. Blood 97:3768-3775 (2001).
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 Research Articles on CD34    1. overexpression in glioma tissues associated closely with higher WHO grade (III + IV) [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD34 antibody Pathways associated with CD34 antibody
 Reference Product  PubMed Publications
 KIT antibody  >2181 publications with CD34 and KIT
 CD33 antibody  >1126 publications with CD34 and CD33
 CD19 antibody  >1061 publications with CD34 and CD19
 VEGFA antibody  >290 publications with CD34 and VEGFA
 PTPRC antibody  >104 publications with CD34 and PTPRC
 MYB antibody  >65 publications with CD34 and MYB
 CRKL antibody  >32 publications with CD34 and CRKL
 SELL antibody  >4 publications with CD34 and SELL
 DNTT antibody  >2 publications with CD34 and DNTT
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with CD34 antibody Organs/Tissues associated with CD34 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2466 publications with CD34 and Cardiovascular Diseases
 Necrosis Antibodies  >1250 publications with CD34 and Necrosis
 Adenocarcinoma Antibodies  >1003 publications with CD34 and Adenocarcinoma
 Anemia Antibodies  >902 publications with CD34 and Anemia
 Breast Neoplasms Antibodies  >888 publications with CD34 and Breast Neoplasms
 Disease Models, Animal Antibodies  >823 publications with CD34 and Disease Models, Animal
 Skin Neoplasms Antibodies  >820 publications with CD34 and Skin Neoplasms
 Inflammation Antibodies  >819 publications with CD34 and Inflammation
 Lung Diseases Antibodies  >761 publications with CD34 and Lung Diseases
 Liver Neoplasms Antibodies  >672 publications with CD34 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17629 publications with CD34 and Blood
 Bone Antibodies  >10553 publications with CD34 and Bone
 Bone Marrow Antibodies  >9883 publications with CD34 and Bone Marrow
 Vascular Antibodies  >5844 publications with CD34 and Vascular
 Muscle Antibodies  >2698 publications with CD34 and Muscle
 Umbilical Cord Antibodies  >1837 publications with CD34 and Umbilical Cord
 Liver Antibodies  >1772 publications with CD34 and Liver
 Skin Antibodies  >1632 publications with CD34 and Skin
 Lung Antibodies  >1196 publications with CD34 and Lung
 Heart Antibodies  >1143 publications with CD34 and Heart
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