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CD4 antibody

Scan QR to view Datasheet Catalog #    MBS439702 CD4 antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Antibody

★Popular Item★
 Also Known As   

CD4 (T-Helper/Inducer Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell antigen T4/LEU3; T cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
 Product Gene Name   

CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186940
 3D Structure    ModBase 3D Structure for P01730
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 Clonality    Monoclonal
 Isotype    IgG2a, kappa
 Clone Number    EDU-2
 Host    Mouse
 Species Reactivity    Human, Chimpanzee, Orangutan, Macaca artctoids (Stumptail Monkey).
Does not react with Macaca mulatta (rhesus Monkey).
Others not tested
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 Specificity    Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. This MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Stimulated human leukocytes
 Hu-Chromosome Location    12p13.31
 Positive Control    Human peripheral blood mononuclear cells (PBMCs), CCRF-CEM or HL-60. Lymph node or tonsil.
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 Preparation and Storage    Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CD4 antibody   

Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for CD4 antibody    Functional Studies (Order Ab without azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    10835167
 NCBI GeneID    920
 NCBI Accession #    NP_000607.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000616.4 [Other Products]
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 UniProt Primary Accession #    P01730 [Other Products]
 UniProt Secondary Accession #    Q4ZGK2; Q5U066; Q9UDE5; B2R737; D3DUS5 [Other Products]
 UniProt Related Accession #    P01730 [Other Products]
 Molecular Weight    55kDa
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 NCBI Official Full Name    T-cell surface glycoprotein CD4 isoform 1
 NCBI Official Synonym Full Names    CD4 molecule
 NCBI Official Symbol    CD4 [Similar Products]
 NCBI Official Synonym Symbols   
CD4mut
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4
 UniProt Protein Name    T-cell surface glycoprotein CD4
 UniProt Synonym Protein Names   
T-cell surface antigen T4/Leu-3; CD_antigen: CD4
 Protein Family    CD40 ligand
 UniProt Gene Name    CD4 [Similar Products]
 UniProt Entry Name    CD4_HUMAN
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 NCBI Summary for CD4    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for CD4    CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: early endosome; endoplasmic reticulum membrane; external side of plasma membrane; lipid raft; plasma membrane

Molecular Function: enzyme binding; glycoprotein binding; MHC class II protein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane receptor activity; zinc ion binding

Biological Process: cell surface receptor linked signal transduction; entry into host cell; enzyme linked receptor protein signaling pathway; induction by virus of cell-cell fusion in host; maintenance of cellular protein localization; positive regulation of protein kinase activity; regulation of defense response to virus by virus; regulation of T cell activation; signal transduction; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; T cell selection; viral envelope fusion with host membrane

Disease: Okt4 Epitope Deficiency
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Product References and Citations for CD4 antibody

   Reinberz EL et al. eds. Leykcocyte Typing II, Springer-Verlag, Berlin, 1985. Knapp W. et. al. (eds) Leukocyte Typing IV, p314-330, Oxford University Press, Oxford, 1989.Sattentau QJ, et al. The CD4 antigen: physiological ligand and HIV receptor. Cell. 1988, 52(5):631-633. Gaubin M, et al. Molecular basis of T lymphocyte CD4 antigen functions. Eur J Clin Chem Clin Biochem. 1996, 34(9):723-728.Mazerolles F, et al. Down regulation of T-cell adhesion by CD4. Hum Immunol. 1991, 31(1):40-6
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 Research Articles on CD4    1. Increased CD4, IL-17, and COX-2 expression are associated with subclinical inflammation in malar melasma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD4 antibody Pathways associated with CD4 antibody
 Reference Product  PubMed Publications
 FOXP3 antibody  >8646 publications with CD4 and FOXP3
 CCR5 antibody  >3463 publications with CD4 and CCR5
 CD2 antibody  >2394 publications with CD4 and CD2
 CD69 antibody  >1947 publications with CD4 and CD69
 CD38 antibody  >1344 publications with CD4 and CD38
 LCK antibody  >843 publications with CD4 and LCK
 IL2RA antibody  >623 publications with CD4 and IL2RA
 PTPRC antibody  >109 publications with CD4 and PTPRC
 CD8A antibody  >94 publications with CD4 and CD8A
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with CD4 antibody Organs/Tissues associated with CD4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >13840 publications with CD4 and Inflammation
 Necrosis Antibodies  >8208 publications with CD4 and Necrosis
 Lung Diseases Antibodies  >7348 publications with CD4 and Lung Diseases
 Liver Diseases Antibodies  >5158 publications with CD4 and Liver Diseases
 AIDS-Related Opportunistic Infections Antibodies  >4514 publications with CD4 and AIDS-Related Opportunistic Infections
 Carcinoma Antibodies  >3765 publications with CD4 and Carcinoma
 Cardiovascular Diseases Antibodies  >3574 publications with CD4 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >2801 publications with CD4 and Vascular Diseases
 Pneumonia Antibodies  >2658 publications with CD4 and Pneumonia
 Asthma Antibodies  >2430 publications with CD4 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >103780 publications with CD4 and Blood
 Spleen Antibodies  >10037 publications with CD4 and Spleen
 Lymph Node Antibodies  >9038 publications with CD4 and Lymph Node
 Bone Antibodies  >7465 publications with CD4 and Bone
 Thymus Antibodies  >7435 publications with CD4 and Thymus
 Lung Antibodies  >7223 publications with CD4 and Lung
 Bone Marrow Antibodies  >6536 publications with CD4 and Bone Marrow
 Liver Antibodies  >6370 publications with CD4 and Liver
 Intestine Antibodies  >3672 publications with CD4 and Intestine
 Brain Antibodies  >3643 publications with CD4 and Brain
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