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anti-CD4 antibody :: anti-Human CD4 Antibody

Scan QR to view Datasheet Catalog #    MBS859599
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Antibody

★Popular Item★
 Also Known As   

CD4 (Phospho-Ser433) Antibody

 Product Synonym Names    CD4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 precursor
 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186940
 3D Structure    ModBase 3D Structure for P01730
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 Species Reactivity    Human
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 Specificity    CD4 (Phospho-Ser433) antibody detects endogenous levels of CD4 only when phosphorylated at serine 433.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human CD4 around the phosphorylation site of serine 433 (R-M-SP-Q-I).
 All Sites    Human: Ser433
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD4 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CD4 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CD4 antibody    IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:40000
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 Testing Data of anti-CD4 antibody    P-peptide-+
anti-CD4 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-CD4 antibody    P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using CD4 (Phospho-Ser433) antibody. Immunofluorescence analysis of HepG2 cells, using CD4 (Phospho-Ser433) antibody.
anti-CD4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    10835167
 NCBI GeneID    920
 NCBI Accession #    NP_000607.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000616.4 [Other Products]
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 UniProt Primary Accession #    P01730 [Other Products]
 UniProt Secondary Accession #    Q4ZGK2; Q5U066; Q9UDE5; B2R737; D3DUS5 [Other Products]
 UniProt Related Accession #    P01730 [Other Products]
 Molecular Weight    51,111 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD4 isoform 1
 NCBI Official Synonym Full Names    CD4 molecule
 NCBI Official Symbol    CD4 [Similar Products]
 NCBI Official Synonym Symbols   
CD4mut
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4
 UniProt Protein Name    T-cell surface glycoprotein CD4
 UniProt Synonym Protein Names   
T-cell surface antigen T4/Leu-3; CD_antigen: CD4
 Protein Family    CD40 ligand
 UniProt Gene Name    CD4 [Similar Products]
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 NCBI Summary for CD4    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for CD4    Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
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Product References and Citations for anti-CD4 antibody

   GR Harriman, J. Immunol., Oct 1990; 145: 2406. G Zauli, Blood, Sep 1994; 84: 1896-1905. Andrew Zloza, Blood, Sep 2003; 102: 2156-2164. David M. Rothstein, Int. Immunol., Jan 1993; 5: 409-418.
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 Research Articles on CD4    1. CD4 has four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide bond. Reduction of D2 disulfide decreases the dynamics of its surrounding beta-strands. Favorable inward collapse of structure occurs around the D2 disulfide after reduction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD4 antibodyPathways associated with anti-CD4 antibody
 Reference Product  PubMed Publications
 CD28 antibody  >3808 publications with CD4 and CD28
 CCR5 antibody  >2893 publications with CD4 and CCR5
 PTPRC antibody  >2767 publications with CD4 and PTPRC
 IL2RA antibody  >2381 publications with CD4 and IL2RA
 env antibody  >2350 publications with CD4 and env
 CD2 antibody  >2277 publications with CD4 and CD2
 CXCR4 antibody  >1971 publications with CD4 and CXCR4
 CD5 antibody  >1560 publications with CD4 and CD5
 CD44 antibody  >1211 publications with CD4 and CD44
 CD38 antibody  >1008 publications with CD4 and CD38
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-CD4 antibodyOrgans/Tissues associated with anti-CD4 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >52584 publications with CD4 and Immune System Diseases
 Neoplasms Antibodies  >14525 publications with CD4 and Neoplasms
 Inflammation Antibodies  >10346 publications with CD4 and Inflammation
 Necrosis Antibodies  >7001 publications with CD4 and Necrosis
 Lung Diseases Antibodies  >6137 publications with CD4 and Lung Diseases
 AIDS-Related Opportunistic Infections Antibodies  >4150 publications with CD4 and AIDS-Related Opportunistic Infections
 Liver Diseases Antibodies  >4111 publications with CD4 and Liver Diseases
 Carcinoma Antibodies  >3071 publications with CD4 and Carcinoma
 Neoplasms, Experimental Antibodies  >2753 publications with CD4 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >2727 publications with CD4 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >88805 publications with CD4 and Blood
 Spleen Antibodies  >8741 publications with CD4 and Spleen
 Lymph Node Antibodies  >7808 publications with CD4 and Lymph Node
 Thymus Antibodies  >6871 publications with CD4 and Thymus
 Bone Antibodies  >6259 publications with CD4 and Bone
 Lung Antibodies  >5881 publications with CD4 and Lung
 Bone Marrow Antibodies  >5561 publications with CD4 and Bone Marrow
 Liver Antibodies  >5190 publications with CD4 and Liver
 Intestine Antibodies  >2983 publications with CD4 and Intestine
 Brain Antibodies  >2947 publications with CD4 and Brain
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