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CD48 antibody

Scan QR to view Datasheet Catalog #    MBS439057 CD48 antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD48, Antibody

 Also Known As   

CD48 (Pan Leukocyte Marker) Mouse Monoclonal Antibody

 Product Synonym Names    B-cell activation marker; B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; BLAST1; CD48 antigen (B cell membrane protein); Signaling lymphocytic activation molecule 2 (SLAMF2); SLAM family member 2
 Product Gene Name   

CD48 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109530
 3D Structure    ModBase 3D Structure for P09326
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    156-4H9
 Host    Mouse
 Species Reactivity    Human.
Others not tested
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 Specificity    Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Human CD48 protein
 Hu-Chromosome Location    1q21.3-q22
 Positive Control    Daudi, JY, Raji, Jurkat, and human lymphocytes. Human lymph node and tonsil.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of CD48 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CD48 antibody   

Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for CD48 antibody    Functional Studies (Order Ab without Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
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NCBI/Uniprot data below describe general gene information for CD48. It may not necessarily be applicable to this product.
 NCBI GI #    21361571
 NCBI GeneID    962
 NCBI Accession #    NP_001769.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001778.3 [Other Products]
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 UniProt Primary Accession #    P09326 [Other Products]
 UniProt Secondary Accession #    Q5U055; Q8MGR0 [Other Products]
 UniProt Related Accession #    P09326 [Other Products]
 Molecular Weight    45kDa
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 NCBI Official Full Name    CD48 antigen isoform 1
 NCBI Official Synonym Full Names    CD48 molecule
 NCBI Official Symbol    CD48 [Similar Products]
 NCBI Official Synonym Symbols   
BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
[Similar Products]
 NCBI Protein Information    CD48 antigen
 UniProt Protein Name    CD48 antigen
 UniProt Synonym Protein Names   
B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; TCT.1; CD_antigen: CD48
 Protein Family    CD48 antigen
 UniProt Gene Name    CD48 [Similar Products]
 UniProt Synonym Gene Names    BCM1; BLAST1; SLAMF2 [Similar Products]
 UniProt Entry Name    CD48_HUMAN
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 NCBI Summary for CD48    This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for CD48    CD48: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q21.3-q22

Cellular Component: integral to plasma membrane; lipid raft; membrane; plasma membrane

Molecular Function: protein binding

Biological Process: defense response; leukocyte migration
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Product References and Citations for CD48 antibody

   Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, New York and London, 1997. Yokoyama S et al. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J Immunol 1991, 146(7):2192-2200. Kwong YL et al. Flow cytometric measurement of glycosylphosphatidyl-inositol-linked surface proteins on blood cells of patients with paroxysmal nocturnal hemoglobinuria. Am J Clin Pathol 1994, 102(1):30-35 Sandrin MS et al. CD48 is a low affinity ligand for human CD2.J Immunol 1993, 151(9):4606-4613. Vaughan HA et al. The isolation of cDNA clones for CD48. Immunogenetics 1991, 33(2):113-117. Vaughan HA et al. Hu Ly-M3--a human leukocyte antigen. Transplantation 1983, 36(4):446-450
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 Research Articles on CD48    1. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD48 antibody Pathways associated with CD48 antibody
 Reference Product  PubMed Publications
 CD244 antibody  >110 publications with CD48 and CD244
 CD4 antibody  >58 publications with CD48 and CD4
 CD84 antibody  >23 publications with CD48 and CD84
 SH2D1A antibody  >20 publications with CD48 and SH2D1A
 LY9 antibody  >15 publications with CD48 and LY9
 LCK antibody  >15 publications with CD48 and LCK
 FYN antibody  >6 publications with CD48 and FYN
 IL18 antibody  >4 publications with CD48 and IL18
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Diseases associated with CD48 antibody Organs/Tissues associated with CD48 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >26 publications with CD48 and Necrosis
 Disease Models, Animal Antibodies  >21 publications with CD48 and Disease Models, Animal
 Inflammation Antibodies  >21 publications with CD48 and Inflammation
 Neoplasms, Experimental Antibodies  >10 publications with CD48 and Neoplasms, Experimental
 Carcinoma Antibodies  >7 publications with CD48 and Carcinoma
 Cardiovascular Diseases Antibodies  >7 publications with CD48 and Cardiovascular Diseases
 Brain Diseases Antibodies  >6 publications with CD48 and Brain Diseases
 Liver Diseases Antibodies  >5 publications with CD48 and Liver Diseases
 Congenital Abnormalities Antibodies  >4 publications with CD48 and Congenital Abnormalities
 Kidney Diseases Antibodies  >3 publications with CD48 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >335 publications with CD48 and Blood
 Bone Marrow Antibodies  >72 publications with CD48 and Bone Marrow
 Spleen Antibodies  >24 publications with CD48 and Spleen
 Lung Antibodies  >16 publications with CD48 and Lung
 Brain Antibodies  >12 publications with CD48 and Brain
 Vascular Antibodies  >9 publications with CD48 and Vascular
 Skin Antibodies  >9 publications with CD48 and Skin
 Thymus Antibodies  >9 publications with CD48 and Thymus
 Placenta Antibodies  >7 publications with CD48 and Placenta
 Lymph Node Antibodies  >7 publications with CD48 and Lymph Node
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