NP_061114.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
NCBI Official Synonym Full Names
beta-1,3-glucuronyltransferase 1
NCBI Official Synonym Symbols
NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP [Similar Products]
NCBI Protein Information
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
UniProt Protein Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
UniProt Synonym Protein Names
Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P; GlcAT-P; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; GlcUAT-P
UniProt Synonym Gene Names
UniProt Entry Name
B3GA1_HUMAN
NCBI Summary for CD57
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CD57
B3GAT1: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Belongs to the glycosyltransferase 43 family.
Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.135; Transferase
Chromosomal Location of Human Ortholog: 11q25
Cellular Component: Golgi membrane
Molecular Function: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Biological Process: carbohydrate metabolic process; chondroitin sulfate metabolic process; chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan metabolic process
Product References and Citations for anti-CD57 antibody
Okada, T., et al. 1995. Origin of CD57+ T cells which increase at tumour sites in patients with colorectal cancer. Clin. Exp. Immunol. 102: 159-166
Research Articles on CD57
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Pathways associated with anti-CD57 antibody
Diseases associated with anti-CD57 antibody
Organs/Tissues associated with anti-CD57 antibody
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