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CD63 antibody

Scan QR to view Datasheet Catalog #    MBS438864
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD63, Antibody

★Popular Item★
 Also Known As   

CD63 (Late Endosomes Marker) Mouse Monoclonal Antibody

 Product Synonym Names    gp55; granulophysin; Lysosomal-associated membrane protein 3 (LAMP-3); Mast cell antigen AD1; melanoma 1 antigen; Melanoma-associated antigen MLA1; Melanoma-associated antigen ME491; MLA1; NGA; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin-30; TSPAN30
 Product Gene Name   

CD63 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    155740
 3D Structure    ModBase 3D Structure for P08962
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    NKI/C3 + LAMP3/968
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic
 Immunogen    Smooth plasma membrane fraction of MeWo cells (NKI/C3); Recombinant human full-length CD63 protein (LAMP3/968)
 Hu-Chromosome Location    12q13.2
 Positive Control    SK-MEL-28, HL60, THP-1 or NIH/3T3 cells. Melanoma or lymphoma.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of CD63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CD63 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for CD63 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of CD63 antibody    Formalin-fixed, paraffin-embedded human Melanoma metastasized to Lung stained with CD63 Monoclonal Antibody (NKI/C3 + LAMP3/968)
CD63 antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of CD63 antibody    Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with CD63 Monoclonal Antibody (NKI/C3 + LAMP3/968)
CD63 antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of CD63 antibody    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with CD63 Monoclonal Antibody (NKI/C3 + LAMP3/968)
CD63 antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD63. It may not necessarily be applicable to this product.
 NCBI GI #    383872447
 NCBI GeneID    967
 NCBI Accession #    NP_001244318.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001257389.1 [Other Products]
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 UniProt Primary Accession #    P08962 [Other Products]
 UniProt Secondary Accession #    Q5TZP3; Q8N6Z9; Q9UCG6; F8VZE2 [Other Products]
 UniProt Related Accession #    P08962 [Other Products]
 Molecular Weight    26kDa (core protein); 30-60kDa (glycosylated)
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 NCBI Official Full Name    CD63 antigen isoform A
 NCBI Official Synonym Full Names    CD63 molecule
 NCBI Official Symbol    CD63 [Similar Products]
 NCBI Official Synonym Symbols   
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
[Similar Products]
 NCBI Protein Information    CD63 antigen
 UniProt Protein Name    CD63 antigen
 UniProt Synonym Protein Names   
Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD_antigen: CD63
 Protein Family    CD63 antigen
 UniProt Gene Name    CD63 [Similar Products]
 UniProt Synonym Gene Names    MLA1; TSPAN30; LAMP-3; Tspan-30 [Similar Products]
 UniProt Entry Name    CD63_HUMAN
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 NCBI Summary for CD63    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
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 UniProt Comments for CD63    CD63: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation. Belongs to the tetraspanin (TM4SF) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q12-q13

Cellular Component: cell surface; endosome membrane; extracellular space; integral to plasma membrane; intrinsic to plasma membrane; late endosome membrane; lysosomal membrane; plasma membrane; platelet dense granule membrane

Molecular Function: protein binding

Biological Process: cell migration; cell-matrix adhesion; pigment granule maturation; platelet degranulation; positive regulation of receptor internalization
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Product References and Citations for CD63 antibody

   Duffield, A., et al. 2003. The tetraspanin CD63 enhances the internalization of the H/K-ATPase beta subunit. Proc. Natl. Acad. Sci. USA 100: 15560-15565
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 Research Articles on CD63    1. CD163(+) TAMs in oral premalignant lesions coexpress CD163 and STAT1, suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1-dominated micromilieu.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD63 antibody Pathways associated with CD63 antibody
 Reference Product  PubMed Publications
 LAMP1 antibody  >38 publications with CD63 and LAMP1
 SRC antibody  >19 publications with CD63 and SRC
 TIMP1 antibody  >13 publications with CD63 and TIMP1
 LAMP2 antibody  >11 publications with CD63 and LAMP2
 NPY antibody  >3 publications with CD63 and NPY
 UBC antibody  >3 publications with CD63 and UBC
 PTK2 antibody  >1 publications with CD63 and PTK2
 SYT7 antibody  >1 publications with CD63 and SYT7
 ITGB1 antibody  >1 publications with CD63 and ITGB1
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with CD63 antibody Organs/Tissues associated with CD63 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >167 publications with CD63 and Cardiovascular Diseases
 Inflammation Antibodies  >140 publications with CD63 and Inflammation
 Carcinoma Antibodies  >63 publications with CD63 and Carcinoma
 Heart Diseases Antibodies  >54 publications with CD63 and Heart Diseases
 Necrosis Antibodies  >45 publications with CD63 and Necrosis
 Breast Neoplasms Antibodies  >29 publications with CD63 and Breast Neoplasms
 Disease Models, Animal Antibodies  >28 publications with CD63 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >28 publications with CD63 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >26 publications with CD63 and Kidney Diseases
 Lung Neoplasms Antibodies  >25 publications with CD63 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1061 publications with CD63 and Blood
 Skin Antibodies  >184 publications with CD63 and Skin
 Vascular Antibodies  >140 publications with CD63 and Vascular
 Lung Antibodies  >80 publications with CD63 and Lung
 Bone Antibodies  >75 publications with CD63 and Bone
 Bone Marrow Antibodies  >59 publications with CD63 and Bone Marrow
 Heart Antibodies  >55 publications with CD63 and Heart
 Kidney Antibodies  >55 publications with CD63 and Kidney
 Brain Antibodies  >48 publications with CD63 and Brain
 Muscle Antibodies  >46 publications with CD63 and Muscle
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