CAG46642.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,420 Da
NCBI Official Full Name
CD86, partial
NCBI Official Synonym Full Names
CD86 molecule
NCBI Official Synonym Symbols
B70; B7-2; B7.2; LAB72; CD28LG2 [Similar Products]
NCBI Protein Information
T-lymphocyte activation antigen CD86
UniProt Protein Name
T-lymphocyte activation antigen CD86
UniProt Synonym Protein Names
Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86
UniProt Synonym Gene Names
NCBI Summary for CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
UniProt Comments for CD86
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Product References and Citations for anti-CD86 antibody
1. Knapp, W et al., eds. (1989) Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York. 2. Lanier LL. et al. (1991) J. Immunol. 146:4421-4426. 3. Campbell, JJ et al. (2001) J. Immunol. 166:6477-6482. 4. Cooper MD et al. (2001) Trends in Immunol. 22:633-640. 5. Galandrini R et al. (2002) Blood. 100:4581-4589.
Research Articles on CD86
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Disclaimer
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Products associated with anti-CD86 antibody
Pathways associated with anti-CD86 antibody
Diseases associated with anti-CD86 antibody
Organs/Tissues associated with anti-CD86 antibody
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