NP_006718.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
88,451 Da
NCBI Official Full Name
cadherin-10 preproprotein
NCBI Official Synonym Full Names
cadherin 10, type 2 (T2-cadherin)
NCBI Protein Information
cadherin-10; T2-cadherin
UniProt Protein Name
Cadherin-10
UniProt Synonym Protein Names
T2-cadherin
UniProt Entry Name
CAD10_HUMAN
NCBI Summary for CDH10
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. [provided by RefSeq, Jan 2011]
UniProt Comments for CDH10
CDH10: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 5p14.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: calcium ion binding
Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; homophilic cell adhesion
Research Articles on CDH10
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Products associated with anti-CDH10 antibody
Pathways associated with anti-CDH10 antibody
Diseases associated with anti-CDH10 antibody
Organs/Tissues associated with anti-CDH10 antibody
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