Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CDK6  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • beta-HCG Native Protein
 • PCNA - Cyclin Antibody
 • Amyloid Fibrils Antibody
 • Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1) Recombinant Protein
 • OTF2A ELISA Kit
 • Intestinal Alkaline Phosphatase (ALPL) Antibody
 • SDMA Antibody
 • Survivin (BIRC5) Antibody
 • ABL1-2 (pY393-439) Blocking Peptide
 • Progesterone Receptor (PGR) Antibody
 • 10x ELISA WASH BUFFER Accessory Reagent
 • Acyl-CoA-binding protein (DBI) Recombinant Protein
 • PLA2G16 Antibody
 • EBNA 3C Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CDK6 antibody :: anti-Human, Mouse CDK6 Antibody

Scan QR to view Datasheet Catalog #    MBS856753
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDK6, Antibody

★Popular Item★
 Also Known As   

CDK6 (phospho-Tyr13) Antibody

 Product Gene Name   

anti-CDK6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603368
 3D Structure    ModBase 3D Structure for Q00534
Section Bar
 Species Reactivity    Human, Mouse
Section Bar
 Specificity    CDK6 (phospho-Tyr13) Antibody detects endogenous levels of CDK6 only when phosphorylated at tyrosine 13.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Section Bar
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human CDK6 around the phosphorylation site of tyrosine 13 (Q-Q-YP-E-C).
Section Bar
 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-CDK6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-CDK6 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CDK6 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CDK6 antibody    IHC: 1:50~100
IF: 1:100~1:200
Section Bar
 Testing Data of anti-CDK6 antibody    P-Peptide - +
Immunohistochemical analysis of paraffin-embedded
human breast carcinoma tissue using CDK6 (phospho-Tyr13) Antibody (E011542).
anti-CDK6 antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CDK6. It may not necessarily be applicable to this product.
 NCBI GI #    223718134
 NCBI GeneID    1021
 NCBI Accession #    NP_001138778.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145306.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q00534 [Other Products]
 UniProt Secondary Accession #    A4D1G0 [Other Products]
 UniProt Related Accession #    Q00534 [Other Products]
 Molecular Weight    36,938 Da
Table BarTOPTable Bar
 NCBI Official Full Name    cyclin-dependent kinase 6
 NCBI Official Synonym Full Names    cyclin dependent kinase 6
 NCBI Official Symbol    CDK6 [Similar Products]
 NCBI Official Synonym Symbols   
MCPH12; PLSTIRE
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase 6
 UniProt Protein Name    Cyclin-dependent kinase 6
 UniProt Synonym Protein Names   
Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE
 Protein Family    Cyclin-dependent kinase
 UniProt Gene Name    CDK6 [Similar Products]
 UniProt Synonym Gene Names    CDKN6 [Similar Products]
Section Bar
 NCBI Summary for CDK6    The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Section Bar
 UniProt Comments for CDK6    Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Table BarTOPTable Bar
 

Product References and Citations for anti-CDK6 antibody

   Lukas, J. et al. (1996) Mol. Cell. Biol. 16, 6917-1625. Hirai, H. et al. (1995) Mol. Cell. Biol. 15, 2672-2681. Flores-Rozas, H. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 8655-8659.
Section Bar
 Research Articles on CDK6    1. Ongoing trials of doublet and triplet targeted therapies containing ribociclib seek to identify optimal CDK4/6-based targeted combination regimens for various tumor types and advance the field of precision therapeutics in oncology
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CDK6 antibodyPathways associated with anti-CDK6 antibody
 Reference Product  PubMed Publications
 CCND1 antibody  >478 publications with CDK6 and CCND1
 CDKN2A antibody  >288 publications with CDK6 and CDKN2A
 CDKN1B antibody  >232 publications with CDK6 and CDKN1B
 CDKN1A antibody  >228 publications with CDK6 and CDKN1A
 CCND3 antibody  >79 publications with CDK6 and CCND3
 CDKN2C antibody  >76 publications with CDK6 and CDKN2C
 CCND2 antibody  >54 publications with CDK6 and CCND2
 CDKN2D antibody  >31 publications with CDK6 and CDKN2D
 CCNE1 antibody  >21 publications with CDK6 and CCNE1
 CCNA2 antibody  >10 publications with CDK6 and CCNA2
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
Diseases associated with anti-CDK6 antibodyOrgans/Tissues associated with anti-CDK6 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >705 publications with CDK6 and Neoplasms
 Carcinoma Antibodies  >222 publications with CDK6 and Carcinoma
 Breast Neoplasms Antibodies  >98 publications with CDK6 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >69 publications with CDK6 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >55 publications with CDK6 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >45 publications with CDK6 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >44 publications with CDK6 and Lung Neoplasms
 Prostatic Neoplasms Antibodies  >42 publications with CDK6 and Prostatic Neoplasms
 Lung Diseases Antibodies  >39 publications with CDK6 and Lung Diseases
 Disease Models, Animal Antibodies  >38 publications with CDK6 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >194 publications with CDK6 and Blood
 Lung Antibodies  >68 publications with CDK6 and Lung
 Bone Antibodies  >66 publications with CDK6 and Bone
 Brain Antibodies  >64 publications with CDK6 and Brain
 Liver Antibodies  >56 publications with CDK6 and Liver
 Prostate Antibodies  >52 publications with CDK6 and Prostate
 Muscle Antibodies  >50 publications with CDK6 and Muscle
 Skin Antibodies  >40 publications with CDK6 and Skin
 Vascular Antibodies  >38 publications with CDK6 and Vascular
 Bone Marrow Antibodies  >35 publications with CDK6 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions