NP_001256.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,520 Da
NCBI Official Full Name
homeobox protein CDX-2
NCBI Official Synonym Full Names
caudal type homeobox 2
NCBI Official Synonym Symbols
NCBI Protein Information
homeobox protein CDX-2; caudal-type homeobox protein 2; caudal type homeobox transcription factor 2; caudal type homeo box transcription factor 2
UniProt Protein Name
Homeobox protein CDX-2
UniProt Synonym Protein Names
CDX-3; Caudal-type homeobox protein 2
UniProt Synonym Gene Names
UniProt Entry Name
CDX2_HUMAN
NCBI Summary for CDX2
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
UniProt Comments for CDX2
CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: nucleoplasm; condensed nuclear chromosome; transcriptional repressor complex
Molecular Function: double-stranded DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: anterior/posterior pattern formation; establishment and/or maintenance of epithelial cell polarity; transcription from RNA polymerase II promoter; blood vessel development; organ morphogenesis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; endosome to lysosome transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; trophectodermal cell differentiation
Research Articles on CDX2
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Products associated with anti-CDX2 antibody
Pathways associated with anti-CDX2 antibody
Diseases associated with anti-CDX2 antibody
Organs/Tissues associated with anti-CDX2 antibody
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