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anti-CELF-1 antibody :: Rabbit CELF-1 Antibody

Scan QR to view Datasheet Catalog #    MBS003103 anti-CELF-1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CELF-1, Antibody

 Also Known As   

Rabbit CELF-1 Antibody

 Product Gene Name   

anti-CELF-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (47487489..47574792, complement). Location: 11p11
 OMIM    601074
 3D Structure    ModBase 3D Structure for Q92879
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CELF-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CELF-1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CELF-1. It may not necessarily be applicable to this product.
 NCBI GI #    71164871
 NCBI GeneID    10658
 NCBI Accession #    NP_001020767.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025596.2 [Other Products]
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 UniProt Primary Accession #    Q92879 [Other Products]
 UniProt Secondary Accession #    Q4LE52; Q9NP83; Q9NR06; B4E2U5; D3DQS0; F8W940 [Other Products]
 UniProt Related Accession #    Q92879 [Other Products]
 Molecular Weight    52,063 Da
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 NCBI Official Full Name    CUGBP Elav-like family member 1 isoform 3
 NCBI Official Synonym Full Names    CUGBP, Elav-like family member 1
 NCBI Official Symbol    CELF1 [Similar Products]
 NCBI Official Synonym Symbols   
CUGBP; NAB50; NAPOR; CUG-BP; CUGBP1; hNab50; BRUNOL2; EDEN-BP
[Similar Products]
 NCBI Protein Information    CUGBP Elav-like family member 1; CELF-1; CUG-BP1; bruno-like 2; EDEN-BP homolog; bruno-like protein 2; CUG RNA-binding protein; deadenylation factor CUG-BP; RNA-binding protein BRUNOL-2; CUG-BP- and ETR-3-like factor 1; CUG triplet repeat RNA-binding protein 1; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA-binding protein 1; embryo deadenylation element binding protein; 50 kDa nuclear polyadenylated RNA-binding protein; nuclear polyadenylated RNA-binding protein, 50-kD; embryo deadenylation element-binding protein homolog
 UniProt Protein Name    CUGBP Elav-like family member 1
 UniProt Synonym Protein Names   
50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Deadenylation factor CUG-BP; Embryo deadenylation element-binding protein homolog; EDEN-BP homolog; RNA-binding protein BRUNOL-2
 UniProt Gene Name    CELF1 [Similar Products]
 UniProt Synonym Gene Names    BRUNOL2; CUGBP; CUGBP1; NAB50; CELF-1; CUG-BP1 [Similar Products]
 UniProt Entry Name    CELF1_HUMAN
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 NCBI Summary for CELF-1    Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CELF-1    CELF1: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. Belongs to the CELF/BRUNOL family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 11p11

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; translation initiation factor binding; RNA binding; translation repressor activity, nucleic acid binding; BRE binding; nucleotide binding

Biological Process: mRNA splice site selection; embryonic development; regulation of RNA splicing; negative regulation of translation; positive regulation of multicellular organism growth; mRNA processing; spermatid development; germ cell development; RNA interference
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 Research Articles on CELF-1    1. study suggests that regulation of CUGBP1 and MBNL1 is essential for accurate control of destabilization of a broad spectrum of mRNAs as well as of alternative splicing events
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CELF-1 antibodyPathways associated with anti-CELF-1 antibody
 Reference Product  PubMed Publications
 DMPK antibody  >20 publications with CELF-1 and DMPK
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with anti-CELF-1 antibodyOrgans/Tissues associated with anti-CELF-1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with CELF-1 and Neoplasms
 Brain Diseases Antibodies  >3 publications with CELF-1 and Brain Diseases
 Congenital Abnormalities Antibodies  >3 publications with CELF-1 and Congenital Abnormalities
 Necrosis Antibodies  >3 publications with CELF-1 and Necrosis
 Neurobehavioral Manifestations Antibodies  >1 publications with CELF-1 and Neurobehavioral Manifestations
 Weight Gain Antibodies  >1 publications with CELF-1 and Weight Gain
 Anemia, Hemolytic Antibodies  >1 publications with CELF-1 and Anemia, Hemolytic
 Infertility, Female Antibodies  >1 publications with CELF-1 and Infertility, Female
 Heart Defects, Congenital Antibodies  >1 publications with CELF-1 and Heart Defects, Congenital
 Fibrosis Antibodies  >1 publications with CELF-1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >31 publications with CELF-1 and Muscle
 Heart Antibodies  >10 publications with CELF-1 and Heart
 Brain Antibodies  >7 publications with CELF-1 and Brain
 Liver Antibodies  >5 publications with CELF-1 and Liver
 Embryonic Tissue Antibodies  >4 publications with CELF-1 and Embryonic Tissue
 Eye Antibodies  >4 publications with CELF-1 and Eye
 Blood Antibodies  >3 publications with CELF-1 and Blood
 Testis Antibodies  >2 publications with CELF-1 and Testis
 Intestine Antibodies  >1 publications with CELF-1 and Intestine
 Skin Antibodies  >1 publications with CELF-1 and Skin
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