NP_001035891.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,001 Da
NCBI Official Full Name
histone H3-like centromeric protein A isoform b
NCBI Official Synonym Full Names
centromere protein A
NCBI Protein Information
histone H3-like centromeric protein A
UniProt Protein Name
Histone H3-like centromeric protein A
UniProt Synonym Protein Names
Centromere autoantigen A; Centromere protein A; CENP-A
UniProt Synonym Gene Names
NCBI Summary for CENPA
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
UniProt Comments for CENPA
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).
Product References and Citations for anti-CENPA antibody
Sullivan K.F., J. Cell Biol. 127:581-592(1994). Hillier L.W., Nature 434:724-731(2005). Shelby R.D., J. Cell Biol. 136:501-513(1997).
Research Articles on CENPA
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Products associated with anti-CENPA antibody
Pathways associated with anti-CENPA antibody
Diseases associated with anti-CENPA antibody
Organs/Tissues associated with anti-CENPA antibody
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