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anti-CEP135 antibody :: Rabbit anti-Human, mouse CEP135 Antibody

Scan QR to view Datasheet Catalog #    MBS003236 anti-CEP135 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CEP135, Antibody

 Also Known As   

Rabbit CEP135 Antibody

 Product Gene Name   

anti-CEP135 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (56814974..56899529). Location: 4q12
 OMIM    611423
 3D Structure    ModBase 3D Structure for Q66GS9
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CEP135 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CEP135 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CEP135. It may not necessarily be applicable to this product.
 NCBI GI #    50083279
 NCBI GeneID    9662
 NCBI Accession #    NP_079285.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_025009.4 [Other Products]
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 UniProt Primary Accession #    Q66GS9 [Other Products]
 UniProt Secondary Accession #    O75130; Q58F25; Q9H8H7; B2RMY0 [Other Products]
 UniProt Related Accession #    Q66GS9 [Other Products]
 Molecular Weight    133,490 Da
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 NCBI Official Full Name    centrosomal protein of 135 kDa
 NCBI Official Synonym Full Names    centrosomal protein 135kDa
 NCBI Official Symbol    CEP135 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    centrosomal protein of 135 kDa; centrosomal protein 4; centrosome protein cep135
 UniProt Protein Name    Centrosomal protein of 135 kDa
 UniProt Synonym Protein Names   
Centrosomal protein 4
 Protein Family    Centrosomal protein
 UniProt Gene Name    CEP135 [Similar Products]
 UniProt Synonym Gene Names    CEP4; KIAA0635; Cep135 [Similar Products]
 UniProt Entry Name    CP135_HUMAN
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 NCBI Summary for CEP135    This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012]
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 UniProt Comments for CEP135    CEP135: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Defects in CEP135 are the cause of microcephaly, primary, type 8 (MCPH8). MCPH8 is a disease defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Belongs to the CEP135/TSGA10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: centriole; centrosome; cytosol

Molecular Function: protein C-terminus binding; protein binding

Biological Process: organelle organization and biogenesis; centriole replication; mitotic cell cycle; G2/M transition of mitotic cell cycle; centriole-centriole cohesion

Disease: Microcephaly 8, Primary, Autosomal Recessive
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 Research Articles on CEP135    1. A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CEP135 antibodyDiseases associated with anti-CEP135 antibody
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway antibodies  Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with CEP135 and Congenital Abnormalities
 Intestinal Neoplasms Antibodies  >1 publications with CEP135 and Intestinal Neoplasms
 Nervous System Malformations Antibodies  >1 publications with CEP135 and Nervous System Malformations
 Neoplasms Antibodies  >1 publications with CEP135 and Neoplasms
Organs/Tissues associated with anti-CEP135 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with CEP135 and Brain
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